Transfected cell immunoblot: extracts of COS cells transfected with GFP-tagged MPP8 and untagged Kv2.1 plasmids and probed with N119/44 (left panel) and K89/34 (right panel) TC supe.
M-Phase Phosphoprotein 8 is encoded by the gene MPHOSPH8. MPHOSPH8 is a heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. MPHOSPH8 is expressed in the brain. Diseases associated with MPHOSPH8 include Charcot-Marie-Tooth Disease.
Fusion protein amino acids 50-120 (Chromo domain) of human MPP8 (also known as m-phase phosphoprotein 8 and MPHOSPH8, accession number Q99549); Rat: 92% identity (66/71 amino acids identical); Mouse: 91% identity (65/71 amino acids identical)
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3)