Anti-Kvbeta1.1 K+ Channel Antibody (K9/40)

Name: Anti-Kvbeta1.1 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-018
Price: 319.0 USD
Availability: InStock

10 Citations

Our Anti-Kvbeta1.1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K9/40. It is KO validated, detects human, mouse, non-human primate, and rat Kvbeta1.1 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Adult rat hippocampus immunohistochemistry.

Immunoblot on adult rat brain membrane (RBM) and lysates from Kvβ1.1 -transfected (COS+) and untransfected (COS-) COS cells.

Adult rat striatum immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-018

Product Details

Target

Kvbeta1.1 K+ channel

Target Description

Voltage-gated potassium channel subunit beta-1 or Kvβ1.1 is encoded by the gene KCNAB1. Kvß1.1 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Alternative splicing of KCNAB1 allows for three distinct proteins to be made, Kvß1.1, Kvß1.2, and Kvß1.3. Each of these has a unique N terminus. Kvβ1.1 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on the channel members. Kvß1 is predominantly expressed in brain and found in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum. Diseases associated with this gene include Episodic Ataxia, Type 1 and Familial Temporal Lobe Epilepsy, 3

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K9/40

Isotype

IgG2b

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnab1 Kvb1

Molecular Weight

44 kDa

Antigen

Synthetic peptide amino acids 7-28 (unique N-terminus) of rat Kv1.1 (TEHNLKSRNGEDRLLSKQSST; accession number NP_058999)

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_10675290

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
ICC: 1:10

Conjugate

Unconjugated

Specificity

Does not cross-react with Kvβ1.2, Kvβ1.3, Kvβ2

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1)

UniProt Details

UniProt (Human): Q14722
UniProt (Immunogen Species): P63143

Product Specific References for Applications and Species

Immunocytochemistry: Mouse | Rat
Western Blot: Human | Mouse | Non-Human Primate | Rat

Immunocytochemistry: Mouse
PMID	Dilution	Publication
33168717	not listed	Cho, I.H., et al. 2020. The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation. . Proceedings of the National Academy of Sciences, 29937-29947.
21507952	1:10	Cheng, L., et al. 2011. Cortactin is required for N-cadherin regulation of Kv1.5 channel function.. The Journal of Biological Chemistry, 20478-89.

Immunocytochemistry: Rat
PMID	Dilution	Publication
27286858	not listed	Cox, R. H., et al. 2016. Functional Expression Profile of Voltage-Gated K(+) Channel Subunits in Rat Small Mesenteric Arteries. Cell Biochemistry and Biophysics, 263-76.
23318870	not listed	Ovsepian, S. V., et al. 2013. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.. The Journal of Physiology, 1771-91.

Western Blot: Human
PMID	Dilution	Publication
35396942	1:1000	Roig, S.R., et al. 2022. S-acylation-dependent membrane microdomain localization of the regulatory Kvβ2. 1 subunit. . Cellular and Molecular Life Sciences, 230.

Western Blot: Mouse
PMID	Dilution	Publication
37114864	1:400	Raph, S.M., et al. 2023. Basal NAD(H) Redox State Permits Hydrogen Peroxide-Induced Mesenteric Artery Dilation. The Journal of Physiology, .
31639389	1:100	Kilfoil, P.J., et al. 2019. Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits.. Journal of Molecular and Cellular Cardiology, 93-106.
21507952	not listed	Cheng, L., et al. 2011. Cortactin is required for N-cadherin regulation of Kv1.5 channel function.. The Journal of Biological Chemistry, 20478-89.

Western Blot: Non-Human Primate
PMID	Dilution	Publication
22426702	not listed	Tipparaju, S. M., et al. 2012. Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating.. Pflügers Archiv: European Journal of Physiology, 799-818.

Western Blot: Rat
PMID	Dilution	Publication
27286858	not listed	Cox, R. H., et al. 2016. Functional Expression Profile of Voltage-Gated K(+) Channel Subunits in Rat Small Mesenteric Arteries. Cell Biochemistry and Biophysics, 263-76.

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Anti-Kvbeta1.1 K+ Channel Antibody (K9/40)

SKU: 75-018

Product Details

Product Specific References for Applications and Species

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