Immunoblot versus extracts from various WT (+/+) and IB2 KO (-/-) mouse brain regions probed with N135/37. Data courtesy of Mitchell Goldfarb (Hunter College) and reproduced with permission from the Journal of Neuroscience (2010 Giza et al, PMID 21048139).
Mitogen-activated protein kinase 8 interacting protein 2 is encoded by the gene MAPK8IP2. MAPK8IP2 is a member of the JIP scaffold family. MAPK8IP2 is a scaffold protein that is involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. MAPK8IP2 has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. MAPK8IP2 is expressed in the brain and testis. Diseases associated with MAPK8IP2 include Cervical Verrucous Carcinoma and Isthmus Cancer.
ICC, IHC, WB
Mapk8ip2 Ib2 Jip2
Fusion protein amino acids 226-421 of mouse JIP-2/IB-2 (also known as C-jun-aminoterminal kinase-interacting protein 2, JNK-interacting protein 2,JNK MAP kinase scaffold protein 2, Islet-brain-2 and Mitogen-activated protein kinase 8-interacting protein 2, accession number Q9ERE9) Rat: 94% identity (127/135 amino acids identical) Human: 86% identity (173/200 amino acids identical) Greater than 50% identity with JIP-1
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)