Anti-JIP-2/IB-2 Antibody (N135/37)

Name: Anti-JIP-2/IB-2 Antibody
Brand: NeuroMab
SKU: 75-163
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

1 Citation

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N135/37

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Mapk8ip2 Ib2 Jip2

Molecular Weight

90 kDa

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Immunoblot versus extracts from various WT (+/+) and IB2 KO (-/-) mouse brain regions probed with N135/37. Data courtesy of Mitchell Goldfarb (Hunter College) and reproduced with permission from the Journal of Neuroscience (2010 Giza et al, PMID 21048139).

Tissue and transfected cell immunoblot: extracts of adult rat brain membrane RBM and COS cells transiently transfected with Flag- tagged JIP-1, JIP-2 or untagged Kv2.1 plasmid and probed with N135/37 (left), mouse anti-Flag (middle) and N52A/42 (right).

Immunoblot versus extracts from various WT (+/+) and IB2 KO (-/-) mouse brain regions probed with N135/37. Data courtesy of Mitchell Goldfarb (Hunter College) and reproduced with permission from the Journal of Neuroscience (2010 Giza et al, PMID 21048139).

Volume: 100 µL

Variant

Price:

$308

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Product Details

Target

JIP-2/IB-2

Target Description

Mitogen-activated protein kinase 8 interacting protein 2 is encoded by the gene MAPK8IP2. MAPK8IP2 is a member of the JIP scaffold family. MAPK8IP2 is a scaffold protein that is involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. MAPK8IP2 has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. MAPK8IP2 is expressed in the brain and testis. Diseases associated with MAPK8IP2 include Cervical Verrucous Carcinoma and Isthmus Cancer.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N135/37

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Mapk8ip2 Ib2 Jip2

Molecular Weight

90 kDa

Antigen

Fusion protein amino acids 226-421 of mouse JIP-2/IB-2 (also known as C-jun-aminoterminal kinase-interacting protein 2, JNK-interacting protein 2,JNK MAP kinase scaffold protein 2, Islet-brain-2 and Mitogen-activated protein kinase 8-interacting protein 2, accession number Q9ERE9) Rat: 94% identity (127/135 amino acids identical) Human: 86% identity (173/200 amino acids identical) Greater than 50% identity with JIP-1

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2140888

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not react with JIP-1

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)

UniProt Details

UniProt (Human): Q13387
UniProt (Immunogen Species): Q9ERE9

Giza J, Urbanski MJ, Prestori F, Bandyopadhyay B, Yam A, Friedrich V, Kelley K, D'Angelo E, Goldfarb M. (2010), 'Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2..' Journal of Neuroscience. 10.1523/JNEUROSCI.1161-10.2010.

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Anti-JIP-2/IB-2 Antibody (N135/37)

Anti-JIP-2/IB-2 Antibody
SKU: 75-163

Bulk Order Anti-JIP-2/IB-2 Antibody

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Anti-JIP-2/IB-2 Antibody (N135/37)

Anti-JIP-2/IB-2 Antibody SKU: 75-163

Bulk Order Anti-JIP-2/IB-2 Antibody

Product Details

Anti-JIP-2/IB-2 Antibody
SKU: 75-163