Homer protein homolog 1 (Homer-1) (VASP/Ena-related gene up-regulated during seizure and LTP 1) (Vesl-1)
Homer Scaffold Protein 1 is encoded by the gene HOMER1. Homer1 is a member of the Homer family of dendritic proteins. Homer1 is a postsynaptic density scaffolding protein which binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1, and SHANK3. HOMER1 is expressed in the skeletal muscle, heart, and brain. Diseases associated with HOMER1 include Phelan-Mcdermid Syndrome, bipolar disorder, autism, fragile x syndrome, and pervasive developmental disorder.
Fusion protein amino acids 121-363 (C-terminus) of mouse Homer1L (also known as Homer protein homolog 1, VASP/Ena-related gene up-regulated during seizure and LTP 1, Vesl-1, Vesl, SYN47 and PSD-Zip45, accession number Q9Z2Y3); Rat: 97% identity (236/243 amino acids identical); Human: 93% identity (226/243 amino acids identical); 30% identity with Homer1S (100% identity between amino acids 121-175, shared sequence of MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFPH); 40% identity with Homer2
Human, Mouse, Rat
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