Guanine nucleotide-binding protein G(s) subunit alpha isoforms short or Gs protein a subunit is encoded by the gene GNAS. Gsa is one of three subunits that make up a guanine nucleotide binding protein (Gprotein). The other proteins are a beta and a gamma subunit. G proteins are further divided into families depending on the type of a subunit included, G(S)alpha,G(Q)alpha,G(I)alpha,and G(12)alpha. Gsa functions as a transducer of numerous signaling pathways that are controlled by g protein coupled receptors (GPCRs) by coupling receptors to adenylyl cyclase and results in increased levels of the signaling molecule cAMP. Diseases associated with GNAS include Mccune-Albright Syndrome and Progressive Osseous Heteroplasia.
Fusion protein amino acids 1-380 (full-length, short form) of bovine Gs protein alpha subunit(also known as Guanine nucleotide-binding protein Gs subunit alpha isoforms short, GNAS, GNAS1, GSP, G-alpha-8 and Adenylate cyclase-stimulating G alpha protein, accession number P04896-2); Human: 99% identity (379/380 amino acids identical); Mouse: 99% identity (378/380 amino acids identical); Rat: 95% identity (377/394 amino acids identical); Significant identity with multiple Guanine nucleotide-binding proteins
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Reacts with both Active and Inactive/QL forms
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)