Anti-Glycine Receptor Alpha3 Antibody (N424/45)

Name: Anti-Glycine Receptor Alpha3 Antibody
Brand: NeuroMab
SKU: 75-417
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, WB

Host Species

Mouse

Gene Name

GLRA3

Molecular Weight

55 kDa

Go to Full Product Details

Immunoblot against extracts of COS cells transiently transfected with untagged GlyRAlpha3L, GlyRAlpha3K or Kv2.1 plasmid probed with N424/45 (left) or K89/34 (right) TC supe.

Product Details

Target

Glycine receptor subunit alpha-3

Target Description

Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission (Schofield et al., 2003). The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin (Fischer et al., 2000). The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins (Beckstead et al., 2001; Mihic et al., 1997). These receptors have also been extremely useful in studies of synaptic clustering of receptors (Craig and Lichtman, 2001). The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor (Chatterton et al., 2002).

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N424/45

Isotype

IgG2a

Applications

ICC, WB

Host Species

Mouse

Gene Name

GLRA3

Molecular Weight

55 kDa

Antigen

Fusion protein amino acids 342-431 (cytoplasmic loop) of human GlyRAlpha3L (also known as Glycine receptor subunit alpha-3 and GLRA3, accession number O75311); Mouse: 95% identity (86/90 amino acids identical); Rat: 93% identity (84/90 amino acids identical)80% identity with GlyRAlpha3K (amino acids 358-372 or TEAFALEKFYRFSDM is L-specific); ~50% identity with GlyRAlpha1 and GlyRAlpha2

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2532050

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Cross-reacts with GlyRAlpha3K

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Glycine receptor subunit alpha-3

UniProt Details

UniProt (Human): O75311
UniProt (Immunogen Species): O75311

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Anti-Glycine Receptor Alpha3 Antibody (N424/45)

Anti-Glycine Receptor Alpha3 Antibody
SKU: 75-417

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Anti-Glycine Receptor Alpha3 Antibody (N424/45)

Anti-Glycine Receptor Alpha3 Antibody SKU: 75-417

Product Details

Anti-Glycine Receptor Alpha3 Antibody
SKU: 75-417