Anti-Glycine Receptor Alpha3 Antibody (N424/45)

Name: Anti-Glycine Receptor Alpha3 Antibody
Brand: NeuroMab
SKU: 75-417
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N424/45

Applications

ICC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

GLRA3

Molecular Weight

55 kDa

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Immunoblot against extracts of COS cells transiently transfected with untagged GlyRAlpha3L, GlyRAlpha3K or Kv2.1 plasmid probed with N424/45 (left) or K89/34 (right) TC supe.

Volume: 100 µL

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Product Details

Target

Glycine receptor Alpha3

Target Description

Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission (Schofield et al., 2003). The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin (Fischer et al., 2000). The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins (Beckstead et al., 2001; Mihic et al., 1997). These receptors have also been extremely useful in studies of synaptic clustering of receptors (Craig and Lichtman, 2001). The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor (Chatterton et al., 2002).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N424/45

Isotype

IgG2a

Applications

ICC, WB

Host Species

Mouse

Gene Name

GLRA3

Molecular Weight

55 kDa

Antigen

Fusion protein amino acids 342-431 (cytoplasmic loop) of human GlyRAlpha3L (accession number O75311) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2532050

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Cross-reacts with GlyRAlpha3K

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Glycine receptor subunit alpha-3

UniProt Details

UniProt (Human): O75311
UniProt (Immunogen Species): O75311

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Anti-Glycine Receptor Alpha3 Antibody (N424/45)

Available Conjugates

Anti-Glycine Receptor Alpha3 Antibody
SKU: 75-417

Bulk Order Anti-Glycine Receptor Alpha3 Antibody

Product Details

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Anti-Glycine Receptor Alpha3 Antibody (N424/45)

Available Conjugates

Anti-Glycine Receptor Alpha3 Antibody SKU: 75-417

Bulk Order Anti-Glycine Receptor Alpha3 Antibody

Product Details

Anti-Glycine Receptor Alpha3 Antibody
SKU: 75-417