Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Gamma- protocadherin-A3 and -A4 and untagged Kv2.1 plasmids and probed with N144/17 (left) and N159/5 (right) TC supe.
Protocadherin gamma A3 is encoded by the gene Pcdhga3. Gamma-protocadherins belong to a superfamily of homophilic cell-adhesion proteins. These cell adhesion proteins are thought to be involved in establishing and function of cell-cell connections in brain. Gamma-Protocadherin-A3 is a type I transmembrane receptor and is a calcium-dependent cell-adhesion protein. Gamma-Protocadherin-A3 plays a role in the establishment and maintenance of specific neuronal connections in the brain. Gamma-Protocadherin-A3 is expressed in the central nervous system where it localizes to synapses. Diseases associated with this gene include Pineal Gland Cancer.
Fusion protein amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma-protocadherin-A3 (also known as PCDH-gamma-A3, accession number Q91XY5); Human: 80% identity (68/84 amino acids identical); Greater than 75% identity with other Gamma-protocadherin-A proteins
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