Anti-GABA-A-R-Epsilon Antibody (N413/67)

Name: Anti-GABA-A-R-Epsilon Antibody
Brand: NeuroMab
SKU: 75-398
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Rat

Clone

N413/67

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

GABRE

Molecular Weight

60 kDa

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Immunoblot against crude membranes and low- speed pellets from adult rat heart (RHM, RHLSP) and brain (RBM, RBLSP) and extracts of COS cells transiently transfected with HA-tagged GABAAREpsilon or untagged Kv2.1 plasmid probed with N413/67 (left) or N52A/42 (right) TC supe.

Adult rat brain immunohistochemistry.

Volume: 100 µL

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Product Details

Target

Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon)

Target Description

Gamma-aminobutyric acid receptor subunit epsilon or GABA AR epsilon is encoded by the gene GABRE. GABA A receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR epsilon is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR epsilon is found expressed in many tissues including adult heart, placenta and adult brain. In brain, GABA AR epsilon is expressed at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N413/67

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

GABRE

Molecular Weight

60 kDa

Antigen

Fusion protein amino acids 27-253 (extracellular N-terminus) of human GABA-A receptor Epsilon (also known as Gamma-aminobutyric acid receptor subunit epsilon and GABRE, accession number P78334); Rat: 75% identity (171/228 amino acids identical); Mouse: 76% identity (163/214 amino acids identical); 50% identity with other GABA-A receptors

Species Reactivity

Human, Rat

Antibody Registry ID

AB_2493101

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon)

UniProt Details

UniProt (Human): P78334
UniProt (Immunogen Species): P78334

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Anti-GABA-A-R-Epsilon Antibody (N413/67)

Anti-GABA-A-R-Epsilon Antibody
SKU: 75-398

Bulk Order Anti-GABA-A-R-Epsilon Antibody

Product Details

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Anti-GABA-A-R-Epsilon Antibody (N413/67)

Anti-GABA-A-R-Epsilon Antibody SKU: 75-398

Bulk Order Anti-GABA-A-R-Epsilon Antibody

Product Details

Anti-GABA-A-R-Epsilon Antibody
SKU: 75-398