Gamma-aminobutyric acid receptor subunit epsilon or GABA AR epsilon is encoded by the gene GABRE. GABA A receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR epsilon is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR epsilon is found expressed in many tissues including adult heart, placenta and adult brain. In brain, GABA AR epsilon is expressed at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane.
Purified
1 mg/mL
Monoclonal
N413/67
IgG2a
ICC, IHC, WB
Mouse
GABRE
60 kDa
Fusion protein amino acids 27-253 (extracellular N-terminus) of human GABA-A receptor Epsilon (also known as Gamma-aminobutyric acid receptor subunit epsilon and GABRE, accession number P78334); Rat: 75% identity (171/228 amino acids identical); Mouse: 76% identity (163/214 amino acids identical); 50% identity with other GABA-A receptors
Human, Rat
AB_2493101
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
