Anti-GABA-A-R-Epsilon Antibody (N413/67)

Name: Anti-GABA-A-R-Epsilon Antibody
Brand: NeuroMab
SKU: 75-398
Price: 337.0 USD
Availability: InStock

Our mouse GABA-A-R-Epsilon monoclonal antibody from NeuroMab is produced in-house from clone N413/67. It detects human and rat GABA-A-R-Epsilon and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Immunoblot against crude membranes and low- speed pellets from adult rat heart (RHM, RHLSP) and brain (RBM, RBLSP) and extracts of COS cells transiently transfected with HA-tagged GABAAREpsilon or untagged Kv2.1 plasmid probed with N413/67 (left) or N52A/42 (right) TC supe.

Adult rat brain immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-398

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

GABA-A-R-Epsilon

Scientific Background

Gamma-aminobutyric acid receptor subunit epsilon or GABA AR epsilon is encoded by the gene GABRE. GABA A receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR epsilon is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR epsilon is found expressed in many tissues including adult heart, placenta and adult brain. In brain, GABA AR epsilon is expressed at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N413/67

Isotype

IgG2a

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

GABRE

Molecular Weight

60 kDa

Immunogen

Fusion protein amino acids 27-253 (extracellular N-terminus) of human GABA-A receptor Epsilon (accession number P78334) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Rat

Antibody Registry ID

AB_2493101

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

gamma-aminobutyric acid receptor subunit epsilon; GABA(A receptor; GABA(A receptor subunit epsilon; epsilon; gamma-aminobutyric acid (GABA A receptor

UniProt ID

P78334
UniProt Summary: Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings. GABARs containing epsilon subunit may regulate cardiac function (Probable).

NCBI Gene ID

2564

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Anti-GABA-A-R-Epsilon Antibody (N413/67)

SKU: 75-398

Product Details

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