Anti-Copper ATPase 1 (Menke's Disease Protein) Antibody FL550 Conjugate (L60/4)

Name: Anti-Copper ATPase 1 (Menke's Disease Protein) Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-142-FL550
Price: 486.0 USD
Availability: InStock

Our mouse Copper ATPase 1 (Menke's disease protein) FL550 conjugate monoclonal antibody from NeuroMab is produced in-house from clone L60/4. It detects human, mouse, and rat Copper ATPase 1 (Menke's disease protein) and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-Copper ATPase 1 (Menke's Disease Protein) Antibody FL550 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-142-FL550

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Copper ATPase 1 (Menke's disease protein)

Scientific Background

Copper-transporting ATPase 1 or ATPase Copper Transporting Alpha is encoded by the gene ATP7A and belongs to the cation transport ATPase (P-type) family. Copper-transporting ATPase 1 is a transmembrane enzyme that functions to provide copper to copper requiring proteins in the Golgi network and is also to remove excess copper across plasma membranes out of the cell. Copper-transporting ATPase 1 is found in most tissues except liver. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

L60/4

Isotype

IgG2b

Applications

ICC, IHC

Host Species

Mouse

Gene Name

ATP7A MC1 MNK

Molecular Weight

180 kDa in rat brain membrane preparations

Immunogen

Synthetic peptide amino acids 42-61 (cytoplasmic N- terminus) of human Copper-transporting ATPase 1 (accession number Q04656)

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939525

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

DSMAX; Copper-transporting ATPase 1; MNK; EC 3.6.3.54; SMAX3; Copper pump 1; Menkes disease-associated protein; ATPase; Cu++ transporting; alpha polypeptide; Cu++-transporting P-type ATPase

UniProt ID

Q04656
UniProt Summary: ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis. Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway. Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions. May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3. In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis.

NCBI Gene ID

538

Shipping

Shipped on ice packs

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Anti-Copper ATPase 1 (Menke's Disease Protein) Antibody FL550 Conjugate (L60/4)

SKU: 75-142-FL550

Product Details

Bulk Order Anti-Copper ATPase 1 (Menke's Disease Protein) Antibody FL550 Conjugate

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