Copper-transporting ATPase 1 or ATPase Copper Transporting Alpha is encoded by the gene ATP7A and belongs to the cation transport ATPase (P-type) family. Copper-transporting ATPase 1 is a transmembrane enzyme that functions to provide copper to copper requiring proteins in the Golgi network and is also to remove excess copper across plasma membranes out of the cell. Copper-transporting ATPase 1 is found in most tissues except liver. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome.
Purified by Protein A chromatography
ATP7A MC1 MNK
180 kDa in rat brain membrane preparations
Synthetic peptide amino acids 42-61 (cytoplasmic N- terminus) of human Copper-transporting ATPase 1 (accession number Q04656)
Human, Mouse, Rat
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL550 Ex: 550 nm, Em: 575 nm
No cross-reactivity reported
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.