Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged CDY1, HA- and Flag- tagged CDYL1 and CDYL2 and untagged Kv2.1 plasmids and probed with N143/38 (left panel), anti-Flag (middle panel) and K89/34 (right panel) TC supe.
This antibody recognizes the proteins Testis-specific chromodomain protein Y 1 and 2 and are encoded by the genes CDY1 and CDY2A respectively. These genes each have a paralog (CDY1B and CDY2B) which are also present on the Y chromosome. Proteins in the CDY-related family contain a chromodomain, involved in chromatin binding, and a histone acetyltransferase catalytic domain. These proteins are expressed in the nucleaus in testis. Diseases associated with these genes include Y-Linked Spermatogenic Failure, and Y Chromosome Infertility.
CDY1 CDY1A; CDY1B
Fusion protein amino acids 6-66 (Chromo domain) of human CDY1 (also known as Testis-specific chromodomain protein Y 1, accession number Q9Y6F8)
100% identity with human CDY273% identity with human CDYL1 (44/60 amino acids identical)
51% identity with human CDYL2 (31/60 amino acids identical)
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity against CDYL1 or CDYL2
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Testis-specific chromodomain protein Y 1 (EC 188.8.131.52)
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