Anti-Cav3.1 Ca2+ Channel Antibody (N178A/9)

Name: Anti-Cav3.1 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-206
Price: 319.0 USD
Availability: InStock

Our Anti-Cav3.1 Ca2+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N178A/9. It is KO validated, detects human, mouse, and rat Cav3.1 Ca2+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Immunoblot of crude brain membranes from adult rat (RBM) and Cav3.1 wild-type (WT) and knockout (KO) mice and probed with N178A/9 (left) and K89/34 (right). Mouse brains courtesy of Stefan Dubel and Jean-Philippe Pin, CNRS.

Mouse brain staining, thalamus and cortex (left) and molecular layer of cerebellum (right). Images courtesy of Laxmi Parajuli and Ryuichi Shigemoto, NIPS.

Adult rat brain immunohistochemistry.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

KO Validated

SKU: 75-206

Volume: 100 µL

Variant

Price:

$319

Quantity:

Product Details

Target

Cav3.1 Ca2+ channel

Target Description

Voltage-dependent T-type calcium channel subunit alpha or Cav3.1 Ca2+ channel is encoded by the gene CACNA1G. Cav3.1 is a pore forming alpha subunit of T voltage-sensitive calcium channels and gives rise to T-type calcium currents. (transient opening calcium channels). These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cav3.1 is expressed in various tissues including heart and smooth muscle, kidney, bone, and brain as a membrane bound protein. Diseases associated with this gene include forms of Spinocerebellar Ataxia

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N178A/9

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Cacna1g

Molecular Weight

>200 kDa

Antigen

Fusion protein amino acids 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1 (accession number Q9WUT2) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2069421

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Voltage-dependent T-type calcium channel subunit alpha

UniProt Details

UniProt (Human): O43497
UniProt (Immunogen Species): Q9WUT2

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Anti-Cav3.1 Ca2+ Channel Antibody (N178A/9)

SKU: 75-206

Product Details

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