Our mouse CASK monoclonal antibody from NeuroMab is produced in-house from clone K56A/50. It detects chicken, human, mouse, non-human primate, rat, Xenopus, and zebrafish CASK and is purified by Protein A chromatography. KO validated. Works in WB, IHC, ICC, IP, ELISA.
Adult rat brain immunohistochemistry.
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Chicken, Human, Mouse, Non-Human Primate, Rat, Xenopus, Zebrafish
Calcium/Calmodulin-Dependent Serine Protein Kinase or CASK scaffolding protein is encoded by the gene CASK. CASK is a member of the MAGUK (membrane-associated guanylate kinase) protein family. CASK is a a calcium/calmodulin-dependent serine protein kinase. CASK is found in many different tissues including kidney, lung, liver and brain. In the brain, CASK protein is located at synapses. CASK acts as a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Mutations in this gene are associated with FG syndrome 4, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
K56A/50
IgG1
ELISA, ICC, IHC, IP, WB
Mouse
CASK LIN2
100 kDa
Fusion protein amino acids 318-415 of human CASK/Lin2 (accession number Q62915) produced recombinantly in E. Coli
Human
Chicken, Human, Mouse, Non-Human Primate, Rat, Xenopus, Zebrafish
AB_2068730
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
WB: 1:1000
IHC: 1:500
ICC: 1:500
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
![Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K56A/50 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-000-k56a-50-wb-2_120x120.jpg?v=1626902818)
KO Validated