Anti-Beta1-Spectrin Antibody (N385/21)

Name: Anti-Beta1-Spectrin Antibody
Brand: NeuroMab
SKU: 75-374
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

SPTB SPTB1

Molecular Weight

250 kDa

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Immunofluorescence staining of optic nerve from adult Beta4-spectrin wild-type (WT) and conditional knockout (cKO) mice with N385/21 (Beta1- spectrin, red), Beta4- spectrin antibody (green) and Neurofascin antibody (blue). Images courtesy of Cheng-Hsin Liu and Matt Rasband (Baylor College of Medicine).

Adult rat hippocampus immunohistochemistry.

Immunofluorescence staining of optic nerve from adult Beta4-spectrin wild-type (WT) and conditional knockout (cKO) mice with N385/21 (Beta1- spectrin, red), Beta4- spectrin antibody (green) and Neurofascin antibody (blue). Images courtesy of Cheng-Hsin Liu and Matt Rasband (Baylor College of Medicine).

Product Details

Target

Spectrin beta chain, erythrocytic (Beta-I spectrin)

Target Description

Spectrin beta chain, erythrocytic, Beta1 spectrin, or Membrane Cytoskeletal Protein is encoded by the gene SPTB and is a member of the member of the spectrin gene family. Beta1 spectrin is primary member of the cytoskeletal network in the erythrocyte plasma membrane. Beta1 spectrin is involved in cell membrane organization and stability and associates with the proteins band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Diseases associated with this gene include Spherocytosis and Elliptocytosis.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N385/21

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

SPTB SPTB1

Molecular Weight

250 kDa

Antigen

Fusion protein amino acids 1555-2137 (C-terminal repeats 13 to 17) of human Beta1-spectrin (also known as Erythrocytic spectrin beta chain, SPTB, SPTB1, Spnb-1, Spnb1 and LOC314251, accession number P11277); Mouse: 90% identity (530/538 amino acids identical); Rat: 90% identity (530/538 amino acids identical); 50% identity with Beta2-spectrin

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315815

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Spectrin beta chain, erythrocytic (Beta-I spectrin)

UniProt Details

UniProt (Human): Q01082
UniProt (Immunogen Species): P11277

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Anti-Beta1-Spectrin Antibody (N385/21)

Anti-Beta1-Spectrin Antibody
SKU: 75-374

Product Details

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Anti-Beta1-Spectrin Antibody (N385/21)

Anti-Beta1-Spectrin Antibody SKU: 75-374

Product Details

Anti-Beta1-Spectrin Antibody
SKU: 75-374