Immunofluorescence staining of optic nerve from adult Beta4-spectrin wild-type (WT) and conditional knockout (cKO) mice with N385/21 (Beta1- spectrin, red), Beta4- spectrin antibody (green) and Neurofascin antibody (blue). Images courtesy of Cheng-Hsin Liu and Matt Rasband (Baylor College of Medicine).
Spectrin beta chain, erythrocytic, Beta1 spectrin, or Membrane Cytoskeletal Protein is encoded by the gene SPTB and is a member of the member of the spectrin gene family. Beta1 spectrin is primary member of the cytoskeletal network in the erythrocyte plasma membrane. Beta1 spectrin is involved in cell membrane organization and stability and associates with the proteins band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Diseases associated with this gene include Spherocytosis and Elliptocytosis.
ICC, IHC, WB
Fusion protein amino acids 1555-2137 (C-terminal repeats 13 to 17) of human Beta1-spectrin (also known as Erythrocytic spectrin beta chain, SPTB, SPTB1, Spnb-1, Spnb1 and LOC314251, accession number P11277); Mouse: 90% identity (530/538 amino acids identical); Rat: 90% identity (530/538 amino acids identical); 50% identity with Beta2-spectrin
Human, Mouse, Rat
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