Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (DNA-binding protein TAXREB67) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)
Cyclic AMP-dependent transcription factor ATF-4, Cyclic AMP-Responsive Element-Binding Protein 2, CREB2 or ATF4 is encoded by the gene ATF4 and is a member of the basic leucine-zipper (bZIP) superfamily. ATF4 is a transcriptional activator believed to be involved in many cell processes. ATF4 is widely expressed in tissues. In brain, ATF4 has been shown to localize in hippocampal neuron dendritic membranes. Diseases associated with ATF4 include Deafness, Mehmo Syndrome and T-Cell Leukemia.
ICC, IHC, WB
ATF4 CREB2 TXREB
Fusion protein amino acids 25-327 (nearly full-length, all but first 24 amino acids) of human ATF4 (also known as Activating transcription factor 4, Cyclic AMP-dependent transcription factor, Cyclic AMP-responsive element-binding protein 2, CREB-2, C/EBP-related ATF, C/ATF, Taxresponsive enhancer element-binding protein 67, DNA-binding protein TAXREB67 and TXREB, accession number P18848); Rat: 86% identity (284/327 amino acids identical); Mouse: 85% identity (280/328 amino acids identical); Less than 50% identity with ATF5
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