Immunoblot against crude membranes from adult rat brain (RBM), mouse brain (MBM) and wild-type (WT) and ATAT1 knockout (KO) mouse brains probed with N347/42 (left) or N52A/42 (right) TC supe. WT and KO mouse brains courtesy of Andrea Aguilar and Max Nachury (Stanford
Alpha-tubulin N-acetyltransferase 1 or ATAT is encoded by the gene ATAT1 and is an enzyme which belongs to the acyltransferase family. ATAT1 functions to acetylate alpha tubulin at Lysine 40. ATAT1 is thought to be involved in microtubule growth, for instance during chemotaxis and the formation of cilium. ATAT1 exists in multiple isotypes. ATAT1 is expressed in many tissues including brain, kidney, retina and testis. Diseases associated with ATAT1 include Von Willebrand Disease, Type 3 and Blood Coagulation Disease.
ATAT1 C6orf134 MEC17 Nbla00487
Fusion protein amino acids 2-236 (N-acetyltransferase domain) of human ATAT1 (also known as Alpha-tubulin N-acetyltransferase 1, Acetyltransferase mec-17 homolog, Alpha-TAT, Alpha-TAT1, TAT, MEC17, C6orf134 and Nbla00487, accession number Q5SQI0); Rat: 94% identity (222/235 amino acids identical); Mouse: 94% identity (221/235 amino acids identical)
Human, Mouse, Rat
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