a-2C adrenergic receptor or a-2 Adrenergic Receptor Subtype C4 is encoded by the gene ADRA2C. It belongs to the Adrenergic receptor subfamily of G-protein coupled receptors. a-2C adrenergic receptors mediate catecholamine-induced inhibition of adenylate cyclase by the action of G proteins. a-2C adrenergic is involved in the regulation of neurotransmitter release from sympathetic nerves and adrenergic neurons. a-2C adrenergic receptors are expressed in brain, kidney and heart. Diseases associated with ADRA2C include Raynaud Phenomenon.
ADRA2C ADRA2L2 ADRA2RL2
50 kDa and larger (possibly due to dimerization)
Synthetic peptide amino acids 442-462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor (also known as Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2CAR, ADRA2C, ADRA2L2 and ADRARL2, accession number P18825); Mouse: 100% identity (21/21 amino acids identical); Rat: 100% identity (21/21 amino acids identical); Greater than 70% identity with Alpha-2B adrenergic receptor
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