Anti-ADAM22 (Extracellular) Antibody (N57/2)

Name: Anti-ADAM22 (Extracellular) Antibody
Brand: NeuroMab
SKU: 75-093
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

KO Validated

2 Citations

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N57/2

Applications

ICC, IP, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Adam22

Molecular Weight

90 kDa

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Immunoblot versus membranes from postnatal day 8 wild-type (wt) and ADAM22-knockout (ko) mice and probed with N46/30 (left) and N57/2 (right). Data courtesy of Dies Meijer, Erasmus University Rotterdam.

Immunoblot versus brain membranes from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Transfected cell immuno- fluorescence showing unpermeabilized COS-1 cells expressing ADAM22.

Adult rat brain membrane immunoblot.

Volume: 100 µL

Variant

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Product Details

Target

ADAM22 (extracellular)

Target Description

ADAM22 is a member of the ADAM (a disintegrin and metalloproteinase) family and predominantly expressed in brain. ADAM 22 is non-catalytic unlike other proteins in the family as it does not contain a zinc binding domain. ADAM22 is a post synaptic neuron receptor for LGI 1 and also binds LGI4. ADAM22 serve as an integrin ligand. Mutations in ADAM22 are implicated in early infantile epileptic encephalopathy-61 and Brachydactyly type C.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N57/2

Isotype

IgG1

Applications

ICC, IP, WB

Host Species

Mouse

Gene Name

Adam22

Molecular Weight

90 kDa

Antigen

Fusion protein amino acids 444-526 (extracellular disintegrin domain) of mouse ADAM22 (accession number Q9R1V6) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2223817

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.20

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22)

UniProt Details

UniProt (Human): Q9R1V6
UniProt (Immunogen Species): Q9R1V6

Dhaunchak AS, Becker C, Schulman H, De Faria O Jr, Rajasekharan S, Banwell B, Colman DR, Bar-Or A; Canadian Pediatric Demyelinating Disease Group. (2012), 'Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis..' Annals of Neurology. 10.1002/ana.22693.
Ogawa Y, Oses-Prieto J, Kim MY, Horresh I, Peles E, Burlingame AL, Trimmer JS, Meijer D, Rasband MN. (2010), 'ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons..' Journal of Neuroscience. 10.1523/JNEUROSCI.4661-09.2010.

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Anti-ADAM22 (Extracellular) Antibody (N57/2)

Available Conjugates

Anti-ADAM22 (Extracellular) Antibody
SKU: 75-093

Bulk Order Anti-ADAM22 (Extracellular) Antibody

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Anti-ADAM22 (Extracellular) Antibody (N57/2)

Available Conjugates

Anti-ADAM22 (Extracellular) Antibody SKU: 75-093

Bulk Order Anti-ADAM22 (Extracellular) Antibody

Product Details

Anti-ADAM22 (Extracellular) Antibody
SKU: 75-093