Human Mouse Rat
ICC IHC WB
Ankyrin-2 or -Ankyrin-B is encoded by the gene ANK2. Ankyrin B is a scaffold protein that functions to link proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. In this manner, ankyrin family proteins play key roles in various processes including cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin B is expressed in brain and muscle. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome.
Fusion protein amino acids 203-496 of human Ankyrin-B (also known as ankyrin-2, brain ankyrin and non-erythroid ankyrin, accession number Q01484); Mouse: 99% identity (292/294 amino acids identical); Rat: 98% identity (291/294 amino acids identical); ~80% identity with Ankyrin-G
No cross-reactivity reported
TC Supernatant: AB_10675129
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.