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Products: Primary Antibodies

Anti-Alpha-2C adrenergic receptor Antibody (N330A/51)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-300
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-300
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG2a

Species Reactivity:

Human Mouse

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC WB

Target Description:

a-2C adrenergic receptor or a-2 Adrenergic Receptor Subtype C4 is encoded by the gene ADRA2C. It belongs to the Adrenergic receptor subfamily of G-protein coupled receptors. a-2C adrenergic receptors mediate catecholamine-induced inhibition of adenylate cyclase by the action of G proteins. a-2C adrenergic is involved in the regulation of neurotransmitter release from sympathetic nerves and adrenergic neurons. a-2C adrenergic receptors are expressed in brain, kidney and heart. Diseases associated with ADRA2C include Raynaud Phenomenon.

Immunogen:

Synthetic peptide amino acids 442-462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor (also known as Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2CAR, ADRA2C, ADRA2L2 and ADRARL2, accession number P18825)
Mouse: 100% identity (21/21 amino acids identical)
Rat: 100% identity (21/21 amino acids identical)
>70% identity with Alpha-2B adrenergic receptor

Cross Reactivity:

Does not cross-react with other adrenergic receptors (based on KO validation results)

Protein Name(s):

Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)

Gene Name(s):

ADRA2C ADRA2L2 ADRA2RL2

Antibody Registry ID:

Purified: AB_2315795
TC Supernatant: AB_2315794


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Knockout Validation:

This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).

Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Molecular Weight:

50 kDa and larger (possibly due to dimerization)


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.