a-2C adrenergic receptor or a-2 Adrenergic Receptor Subtype C4 is encoded by the gene ADRA2C. It belongs to the Adrenergic receptor subfamily of G-protein coupled receptors. a-2C adrenergic receptors mediate catecholamine-induced inhibition of adenylate cyclase by the action of G proteins. a-2C adrenergic is involved in the regulation of neurotransmitter release from sympathetic nerves and adrenergic neurons. a-2C adrenergic receptors are expressed in brain, kidney and heart. Diseases associated with ADRA2C include Raynaud Phenomenon.
Synthetic peptide amino acids 442-462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor (also known as Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2CAR, ADRA2C, ADRA2L2 and ADRARL2, accession number P18825)
Mouse: 100% identity (21/21 amino acids identical)
Rat: 100% identity (21/21 amino acids identical)
>70% identity with Alpha-2B adrenergic receptor
Does not cross-react with other adrenergic receptors (based on KO validation results)
Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)
ADRA2C ADRA2L2 ADRA2RL2
TC Supernatant: AB_2315794
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
50 kDa and larger (possibly due to dimerization)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.