TrkB-Fc Chimera, Human, Purified Recombinant Protein

Name: TrkB-Fc Chimera, Human, Purified Recombinant Protein
Brand: Biosensis
SKU: PE-1236-50
Price: 527.0 USD
Availability: InStock

Tyrosine Kinase Receptor B (TrkB)-Fc Chimera, purified human recombinant protein, suitable to block.

Gel analysis of TrkC-Fc Chimera.

Lane 1: MW marker
Lane 2: TrkC-Fc Chimera (5 µg)
Lane 3: TrkC-Fc Chimera (5 µg) treated with PNGase F to remove potential N-linked glycans
Lane 4: TrkC-Fc Chimera (5 µg) treated with a glycosidase cocktail to remove potential N- and O-linked glycans

Click on image to zoom

Applications

Block

Host Species

HEK293

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Data Sheet

SKU: PE-1236-50

Volume/Size: 50 µg

Variant

Price:

$527.00

Quantity:

Product Details

Target

Tyrosine Kinase Receptor C (TrkC)

Scientific Background

TrkC is a member of the tropomyosin-related kinase receptor family. TrkC is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC is the receptor for neurotrophin-3 (NT-3). Signalling through TrkC leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. TrkC is a heavily glycosylated molecule with 13 potential N-linked glycosylation sites within the extracellular domain.

Format

Purified. The TrkC-Fc chimera consists of 15-55% carbohydrate by weight.

Applications

Block

Host Species

HEK293

Protein Sequence

A DNA sequence encoding the signal peptide and extracellular domain of human TrkC (amino acids 1-428) was fused to the Fc region of human IgG1 (amino acids 93-330). The chimeric protein was expressed in modified human 293 cells.

Storage

It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial. Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 2-8°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

Physical State

Lyophilized

Production Notes

>95% purity, as determined by SDS-PAGE and visualized by silver stain.

Buffer

When reconstituted in 0.5 mL sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Tropomyosin-related kinase receptor; NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC; TrkC-Fc Chimera

UniProt ID

Q16288

Shipping

25°C (ambient)

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TrkB-Fc Chimera, Human, Purified Recombinant Protein

SKU: PE-1236-50

Product Details

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