Human Mouse Rat Zebrafish
IHC IP WB
Voltage-gated potassium channel subunit beta-2 or Kvß2 is encoded by the gene KCNAB2. Kvß2 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Kvß2 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. Kvß2 is expressed in brain, in thecerebellum and in the juxtaparanodal region of nodes of Ranvier. Kvß2 expression is also detected in lung, heart and kidney. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome and Juvenile Amyotrophic Lateral Sclerosis 16,
Fusion protein amino acids 1-367 (full length) of rat Kv2 (accession number NP_034728)Epitope mapped to within amino acids 17-22; Human: 98% identity (362/367); Mouse: 100% identity
No cross-reactivity reported
Kvbeta2 K+ channel
Kcnab2 Ckbeta2 I2rf5 Kcnb3
TC Supernatant: AB_10673520
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
38 kDa (major band)41 kDa (minor band)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.