When it comes to BDNF antibody-based research, choose your antibodies wisely
Immunostaining of neurotrophic factors has historically been challenging because these small, transient proteins, often with multiple isoforms, can create problems with reliable, accurate, interpretable staining if the immunogens and resultant antibodies are not well designed. BDNF is a case in point. Researchers focused on the crucial roles of Brain-Derived Neurotrophic Factor (BDNF) in neuroplasticity, memory, aging, Alzheimer's disease, depression, etc. struggled for years to make or buy commercial antibodies for reliable detection. Ultimately, many of the most reliable, high-precision BDNF antibodies were made in neurotrophin research labs and then licensed to companies for distribution.
Access to precision BDNF antibodies developed by neurotrophin researchers
Dr. Robert Rush, a pioneering neurotrophin researcher at Flinders University, developed a number of key antibodies still used as gold standards in the field today and sold by the company he started: “Biosensis. As leaders in neurotrophin antibodies for over three 3-decades, Biosensis offers validated monoclonal and polyclonal anti-BDNF antibodies ideal for detecting and studying this vital protein in cell signaling pathways.” Biosensis versatile BDNF ELISA, IHC, ICC, and western blot solutions enable clear BDNF protein detection across rodent, human, and other model systems.
Biosensis drives BDNF research forward with accurate and reliable antibodies
"Our antibody engineering team has a deep knowledge of BDNF biology and signaling," explains Dr. Lyndon M Foster, MS., Ph.D., Chief Technical Officer at Biosensis. "By optimizing highly specific antibodies targeting the BDNF multiple functional isoforms, we provide researchers the exacting tools they need to elucidate neurotrophin pathways underlying health and disease." From purified rabbit anti-BDNF to whole serum antibodies, Biosensis' portfolio enables clear visualization and quantification of 14kDa, 18kDa, and 28kDa BDNF forms in homogenates, lysates, cells, and tissue. “Our robust affinity purified and polyclonal or monoclonal antibodies showcase high specificity in low concentrations, can use diverse substrates, and allow precision detection in multiple facets of BDNF biology from development to cell signaling,” states Dr. Foster. So whether your research involves immunohistochemistry, flow cytometry, or simple western blots, trust Biosensis first for the versatile BDNF antibodies today's neuroscience demands. Invest in tools built by neurotrophin experts who understand the importance of reproducibility in this vital field. Request your high-precision BDNF antibodies today!
Figure 2: R-088-100. BDNF expression analyzed via Western blot: 18 kDa isoform in human serum (A) and a 28 kDa band in human brain (B), indicating BDNF dimer or truncated isoform.
Keynote Published Antibodies
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R-083-100 |
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M-1736-100 |
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S-015-500 |
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M-1744-100 |