When placing orders, please note whether your facility is currently receiving packages

Products: Primary Antibodies

Anti-LAR/PTPRF (Receptor-type tyrosine-protein phosphatase) Antibody (N165/38)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-193
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-193
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG2a

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC WB

Target Description:

Receptor-type tyrosine-protein phosphatase F or Leukocyte Common Antigen Related protein is encoded by the gene PTPRF and is a member of the protein tyrosine phosphatase (PTP) family. PRPRF is a transmembrane protein involved in regulation of insulin signaling, cell proliferation and cell migration. PTPRF functions in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. PTPRF is ubiquitously expressed. Diseases associated with PTPRF include Aplasia or hypoplasia of the breasts and/or nipples 2

Immunogen:

Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (also known as Leukocyte antigen related, Leukocyte common antigen-related phosphatase, Receptor-type tyrosine-protein phosphatase F and PTPRF, accession number P10586); Rat: 97% identity (286/293 amino acids identical); Mouse: 97% identity (285/293 amino acids identical); Greater than 80% identity with PTPRD and PTPRS; Greater than 50% identity with PTPRM and PTPRK

Cross Reactivity:

Does not cross-react with PTPRD or PTPRS

Protein Name(s):

LAR/PTPRF (Receptor-type tyrosine-protein phosphatase)

Gene Name(s):

PTPRF LAR

Antibody Registry ID:

Purified: AB_10675291
TC Supernatant: AB_10673278


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Molecular Weight:

85 kDa(full-length is 210 kDa, smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains)


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.