Human Mouse Rat
Receptor-type tyrosine-protein phosphatase F or Leukocyte Common Antigen Related protein is encoded by the gene PTPRF and is a member of the protein tyrosine phosphatase (PTP) family. PRPRF is a transmembrane protein involved in regulation of insulin signaling, cell proliferation and cell migration. PTPRF functions in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. PTPRF is ubiquitously expressed. Diseases associated with PTPRF include Aplasia or hypoplasia of the breasts and/or nipples 2
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (also known as Leukocyte antigen related, Leukocyte common antigen-related phosphatase, Receptor-type tyrosine-protein phosphatase F and PTPRF, accession number P10586); Rat: 97% identity (286/293 amino acids identical); Mouse: 97% identity (285/293 amino acids identical); Greater than 80% identity with PTPRD and PTPRS; Greater than 50% identity with PTPRM and PTPRK
Does not cross-react with PTPRD or PTPRS
LAR/PTPRF (Receptor-type tyrosine-protein phosphatase)
TC Supernatant: AB_10673278
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
85 kDa(full-length is 210 kDa, smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.