Human Mouse Rat
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (also known as Leukocyte antigen related, Leukocyte common antigen-related phosphatase, Receptor-type tyrosine-protein phosphatase F and PTPRF, accession number P10586)
Rat: 97% identity (286/293 amino acids identical)
Mouse: 97% identity (285/293 amino acids identical)
>80% identity with PTPRD and PTPRS
>50% identity with PTPRM and PTPRK
Does not cross-react with PTPRD or PTPRS
Receptor-type tyrosine-protein phosphatase F (EC 188.8.131.52) (Leukocyte common antigen related) (LAR)
TC Supernatant: AB_10673278
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
85 kDa(full-length is 210 kDa, smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Song YS, Lee HJ, Prosselkov P, Itohara S, Kim E.. (2013), 'Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. .' Journal of Cell Science. 10.1242/jcs.129718. " "
- van der Veer EP, de Bruin RG, Kraaijeveld AO, de Vries MR, Bot I, Pera T, Segers FM, Trompet S, van Gils JM, Roeten MK, Beckers CM, van Santbrink PJ, Janssen A, van Solingen C, Swildens J, de Boer HC, Peters EA, Bijkerk R, Rousch M, Doop M, Kuiper J, Schalij MJ, van der Wal AC, Richard S, van Berkel TJ, Pickering JG, Hiemstra PS, Goumans MJ, Rabelink TJ, de Vries AA, Quax PH, Jukema JW, Biessen EA, van Zonneveld AJ.. (2013), 'Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype. .' Circulation Research. 10.1161/CIRCRESAHA.113.301302. "