Products: Primary Antibodies

Anti-GluN1/NR1 Glutamate Receptor Antibody (N308/48)

NeuroMab Logo from NeuroMab

 Datasheet

Product Summary:

Detect GluN1/NR1 Glutamate Receptor with this antibody validated for IHC, WB, ICC.

PRODUCT OPTIONS

★ Trial Size Available ★
Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-272
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$325.00
Brand
NeuroMab Logo
Catalog #
75-272-020
Option
Purified Trial-Size
Volume
20 µL
Concentration
1 mg/mL
Price
$109.00
Brand
NeuroMab Logo
Catalog #
73-272
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$325.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC IHC WB

Target Description:

Glutamate receptor 1, NMDA 1, or GluN1/NR1 also known as subunit 1 of the N-methyl-D-aspartate (NMDA) receptor. It is a member of the glutamate receptor channel superfamily and is a heteromeric glutamate-gated calcium ion channel. GluN1 is essential for synaptic function in the brain. GluN1 is expressed throughout the brain in cerebellum, thalamus, olfactory bulb and cortex in the membrane at postsynaptic density. GluN1 plays a key role in synaptogenesis, synaptic plasticity, memory acquisition and learning. Mutations in the GluN1 gene are associated with intellectual disability and cortical visual impairment and movement disorders.

Immunogen:

Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1(also known as N-methyl-D-aspartate receptor subunit NR1, NMDAR1, NMD-R1, GRIN1, Glutamate receptor subunit zeta-1 and Glurz1, accession number P35439) Mouse: 99% identity (319/320 amino acids identical)
Human: 99% identity (317/320 amino acids identical)
<50% identity with other Glutamate receptors

Protein Name(s):

Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)

Gene Name(s):

Grin1 Nmdar1

Antibody Registry ID:

Purified: AB_11000180
Purified Trial-Size: AB_11000180
TC Supernatant: AB_11001716


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

105 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.


Citations and References