Anti-CALB1/calbindin Antibody (L109/57)

Name: Anti-CALB1/calbindin Antibody
Brand: NeuroMab
SKU: 75-448
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

L109/57

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

CALB1 CAB27

Molecular Weight

30 kDa

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Array tomography immunofluorescence of Lowicryl-embedded sections from adult mouse cerebellum with L109/57 (red) and DAPI (blue). Left panel is a single 70 nm section imaged with a 20X objective, with a scale bar of 50 µm. Right panel is a MAX projection of 10 serial 70 nm sections imaged with a 63X objective, with a scale bar of 20 µm. Images courtesy of Kristina Micheva (Stanford)..

Adult rat hippocampus immunohistochemistry.

Array tomography immunofluorescence of Lowicryl-embedded sections from adult mouse cerebellum with L109/57 (red) and DAPI (blue). Left panel is a single 70 nm section imaged with a 20X objective, with a scale bar of 50 µm. Right panel is a MAX projection of 10 serial 70 nm sections imaged with a 63X objective, with a scale bar of 20 µm. Images courtesy of Kristina Micheva (Stanford)..

Volume: 100 µL

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Product Details

Target

CALB1/calbindin

Target Description

Calbindin (aka. calbindin D28k) is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is predominantly expressed in certain types of neurons, particularly in dendrites and perikarya of the cerebellum and is thought to buffer entry of calcium upon stimulation of glutamate receptors (Andressen et al., 1993). Calbindin has recently been shown to play a critical role in mitochondrial dysfunction and loss of synaptic proteins in vivo in an Alzheimer’s disease mouse model (Kook et al., 2014).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L109/57

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

CALB1 CAB27

Molecular Weight

30 kDa

Antigen

Fusion protein amino acids 1-261 (full-length) of human CALB1 (accession number P05937) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2686913

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Calbindin (Calbindin D28) (D-28K) (Vitamin D-dependent calcium-binding protein, avian-type)

UniProt Details

UniProt (Human): P05937
UniProt (Immunogen Species): P05937

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Anti-CALB1/calbindin Antibody (L109/57)

Anti-CALB1/calbindin Antibody
SKU: 75-448

Bulk Order Anti-CALB1/calbindin Antibody

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Anti-CALB1/calbindin Antibody (L109/57)

Anti-CALB1/calbindin Antibody SKU: 75-448

Bulk Order Anti-CALB1/calbindin Antibody

Product Details

Anti-CALB1/calbindin Antibody
SKU: 75-448