Anti-Kv2.1 Potassium Channel Subunit Antibody (BSA and Azide free) (L80/21)

Name: Anti-Kv2.1 Potassium Channel Subunit Antibody (BSA and Azide free)
Brand: NeuroMab
SKU: 75-315-CF
Price: 475.0 USD
Availability: InStock

Our carrier-free Anti-Kv2.1 potassium channel subunit mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L80/21. It is KO validated, detects human, mouse, and rat Kv2.1 potassium channel subunit, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Anti-Kv2.1 Potassium Channel Subunit Antibody (BSA and Azide free)

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

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Data Sheet

KO Validated

SKU: 75-315-CF

Volume: 100 µL

Variant

Price:

$475.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv2.1 potassium channel subunit

Scientific Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L80/21

Isotype

IgG3

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Immunogen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (accession number P15387)

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.

Buffer

PBS

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

UniProt ID

P15387

Shipping

Shipped on ice packs

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Anti-Kv2.1 Potassium Channel Subunit Antibody (BSA and Azide free) (L80/21)

SKU: 75-315-CF

Product Details

Bulk Order Anti-Kv2.1 Potassium Channel Subunit Antibody (BSA and Azide free)

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