alpha-Bungarotoxin, Fluorescein Conjugate

Name: alpha-Bungarotoxin, Fluorescein Conjugate
Brand: Antibodies Incorporated
SKU: 81-1202
Price: 469.0 USD
Availability: InStock

Our alpha-Bungarotoxin is a potent neurotoxin widely used to study neuromuscular junctions by blocking cholinergic receptors. Our fluorescein conjugate is membrane impermeant and works well in live/intact cells and cells fixed in formaldehyde or methanol.

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Applications

EM, ICC, IHC

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SKU: 81-1202

Size: 10 x 50 µg

Variant

Price:

$469.00

Quantity:

Ships: 1-5 business days

Product Details

Scientific Background

alpha-Bungarotoxin is a high affinity inhibitor (Kd = 1 nM to 1 pM) of the nicotinic acetylcholine receptor in the neuromuscular junction and blocks acetylcholine activity at the postsynaptic membrane. It is often used to study neuromuscular junctions by blocking cholinergic receptors. The effects of α-bungarotoxin on neuronal nAChR have been shown to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM). Labeled α-bungarotoxin conjugates can be used for staining nicotinic acetylcholine receptors at neuromuscular junctions in tissue sections.

Applications

EM, ICC, IHC

Excitation / Emission

FITC Ex: 498 nm, Em: 517 nm

Storage

Store at –20°C, with desiccant; protect from light.

Physical State

Solid

Conjugate

FITC

Specificity

Membrane impermeant; works in live/intact cells and cells fixed in formaldehyde or methanol.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

Stable for 12 months after date of receipt.

Synonyms

neurotoxin, nicotinic (a7) receptor antagonist

Shipping

Shipped at ambient temperature with desiccant; protected from light

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alpha-Bungarotoxin, Fluorescein Conjugate

SKU: 81-1202

Product Details

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