Centromere Image

Contributed by Kameron Simpson

Transcending their origin in human CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) patient serum, Anti-Centromere antibodies serve as crucial reagents for cell biologists and as controls in Antinuclear Antibody (ANA) diagnostics.

The anti-centromere antibody (ACA) belongs to the category of autoantibodies, which are proteins generated by the immune system erroneously targeting the body's own tissues. More precisely, it falls within the group of antinuclear antibodies and specifically directs its focus to the centromere—a vital component of the chromosomes located within the nucleus of the body's cells

What sets ACAs apart is their remarkable ability to extend their influence beyond the human immune system. These antibodies showcase their versatility by reacting with a variety of species, making them extremely useful tools in laboratory settings. The reactivity of ACAs with mouse, rat, and hamster centromere proteins opens new avenues for research and experimentation, allowing scientists to explore autoimmune phenomena across different organisms.

As laboratories continue to unravel the complexities of autoimmune diseases and DNA replication, these antibodies stand as versatile tools, bridging the gap between human and animal models. The story of Anti-Centromere Antibodies is one of adaptability and exploration, paving the way for advancements in cell biology research and diagnostics.


Product Specific References for Anti-Centromere Protein Antibody

    Product Number: 15-234, antisera
    PMID Application: Species Publication
    38059900 ICC: human Paul, S, et al. 2024. NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis. The Journal of Cell Biology, .
    38177531 ICC: mouse Molina, O, et al. 2023. Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression. EMBO Molecular Medicine, 64-92.
    38066646 IHC: human Yang, Y, et al. 2023. Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation. BMC Biology, 285.
    38244729 IHC: mouse Zhang, M., et al. 2024. Prothioconazole exposure disrupts oocyte maturation and fertilization by inducing mitochondrial dysfunction and apoptosis in mice. Free Radical Biology & Medicine, 274-284.
    38218586 IHC: mouse Zhang, M., et al. 2024. Copper oxide nanoparticles impairs oocyte meiosis maturation by inducing mitochondrial dysfunction and oxidative stress. Food and Chemical Toxicology, 114441.
    Product Number: 15-235, purified
    PMID Application: Species Publication
    37484914 ICC: human Didaskalou, S, et al. 2023. HURP Localization in Metaphase is the Result of a Multi-step Process Requiring its Phosphorylation at Ser627 Residue. Frontiers in cell and developmental biology, 981425.
    36836858 IHC: fish (lamprey) Matveevsky, S., et al. 2023. The First Analysis of Synaptonemal Complexes in Jawless Vertebrates: Chromosome Synapsis and Transcription Reactivation at Meiotic Prophase I in the Lamprey …. Life, 501.