Tyrosine Hydroxylase (TH):
A feature common to all neurodegenerative parkinsonian disorders is loss of dopaminergic neurons of the substantia nigra. TH is the rate-limiting enzyme in the biosynthesis of catecholamines, including the neurotransmitter dopamine, and is widely used as a marker of dopaminergic neurons.
Our mouse monoclonal anti-Tyrosine Hydroxylase antibody LNC1 is the most widely-cited anti-TH antibody in the literature with over 2,500 citations to date.
For researchers needing to multiplex their anti-Tyrosine Hydroxylase staining with antibodies from alternative host species we also offer the following highly quality anti-TH antibodies:
Mutations in LRRK2 represent the most common cause of inherited Parkinson's disease. A recent study comparing different commercially available anti-LRRK2 antibodies found that our anti-LRRK2 antibody N241A/34 is the best option for multiple different uses in rat, mouse, and human samples as the antibody of choice for Immunoblot, IP, ICC, and IHC.
Want to learn more about LRRK2 function and it’s role in disease? Read our recent article here.
In addition to dopaminergic neuron loss in PD another hallmark of the disease is the accumulation of the protein alpha-synuclein within neurons into intracellular protein inclusions termed Lewy bodies. Alpha-synuclein accumulation into such aggregates can be reliably detected with anti-alpha synuclein antibodies. To allow for flexibility in multiplexing experiments where antibodies from multiple hosts are required we offer our chicken anti-alpha synuclein antibody
Discover additional antibodies for Parkinson’s disease and neuroscience research including PINK1 from our family of antibody companies.