Anti-Small ubiquitin-related modifier 1 (SUMO-1) Antibody

Name: Anti-Small ubiquitin-related modifier 1 (SUMO-1) Antibody
Brand: Biosensis
SKU: R-115-100
Price: 337.0 USD
Availability: InStock

Our Anti-Small ubiquitin-related modifier 1 (SUMO-1) rabbit polyclonal primary antibody detects human and rat Small ubiquitin-related modifier 1 (SUMO-1), and is whole serum. It is validated for use in IHC-Frozen, WB.

Western blot detection of recombinant SUMO-1 protein using Rabbit antibody to SUMO-1 (6-21): ws (catalogue no. R-115-100) at a dilution of 1:4000. The protein sample was 1 µl of E.Coli cell lysate containing approximately 50 ng of recombinant SUMO-1 protein. The antibody detects a band of 17 kDa.

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Species Reactivity

Human, Rat

Applications

IHC, WB

Host Species

Rabbit

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Data Sheet

SKU: R-115-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Product Details

Target

Small ubiquitin-related modifier 1 (SUMO-1)

Scientific Background

FUNCTION: Ubiquitin-like protein which binds to a wide range of target proteins. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. SUBUNIT: Covalently attached to a number of proteins such as PmL, RANGAP1, HIPK2, SP100, p53, p73alpha, MDM2, JUN and DNMT3B. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, PIAS1, EXOSC9, TDG, RAD51 and RAD52. SUBCELLULAR LOCATION: Nucleus; nuclear membrane. Nucleus; nucleoplasm; nuclear speckle. Cytoplasm. SIMILARITY: Belongs to the ubiquitin family. SMT3 subfamily. SIMILARITY: Contains 1 ubiquitin-like domain.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC, WB

Host Species

Rabbit

Immunogen

A synthetic peptide (AKPSTEDLGDKKEGEY) as part of human SUMO-1 peptide (aa: 6-21) conjugated to diphtheria toxoid has been used as the immunogen. This antigen is homologous with SUMO-1 of rat.

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

WB: 1:2000-1:4000
IHC: 1:1000-1:2000

Application Details

Cell lysate from Hela and NIH-3T3 cell lysates may be used as a positive control, and for IHC, lung carcinoma may be used.

Conjugate

Unconjugated

Specificity

This antiserum recognizes human SUMO-1 and not ubiquitin. This antiserum is known to cross react with rat and human SUMO-1.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Small ubiquitin-related modifier 1; Ubiquitin-like protein SMT3C; SMT3 homolog 3; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein UBL1; GAP-modifying protein 1; GMP1; Sentrin; SUMO1; SMT3C; SMT3H3; UBL1

UniProt ID

P63165

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Anti-Small ubiquitin-related modifier 1 (SUMO-1) Antibody

SKU: R-115-100

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