Immunoblot versus crude cardiac mitochondrial preps from WT, Mfn2 KO Mfn1 KO mice and probed with N111/24 TC supe. Samples courtesy of Dr. Suzanne Hoppins, Dr. Laura Lackner and Dr. Jodi Nunnari, UCDavis.
Mitofusin 1, or transmembrane GTPase Mfn1 (MFN1) is a mitochondrial membrane protein with GTPase activity that functions to aid mitochondrial clustering and fusion. It may also play a role in mitochondrial metabolism. It is expressed in the outer membrane of mitochondria in many tissues, including heart and testis. Diseases associated with MFN1 include Optic Atrophy 1 and Autosomal Recessive Spastic Paraplegia .
Fusion protein amino acids 350-580 of mouse Mitofusin-1 (also known as transmembrane GTPase Mfn1, accession number Q811U4); Rat: 99% identity (229/231 amino acids identical); Human: 89% identity (207/231 amino acids identical); ~55 % identity with Mitofusin-2
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity against Mitofusin-2
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.