Anti-LRRK1 Antibody (N341/12)

Name: Anti-LRRK1 Antibody
Brand: NeuroMab
SKU: 75-347
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

filler

Clonality

Monoclonal

Applications

ICC, WB

Host Species

Mouse

Gene Name

LRRK1 KIAA1790

Molecular Weight

>200 kDa

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Immunoblot versus LRRK1-immunoprecipitated extracts from WT and LRRK1 KO mouse heart probed with N341/12 TC supe. Data courtesy of Paul Davies and Dario Alessi (University of Dundee, Scotland, UK.

Transfected cell immunoblot: extracts of COS cells transiently transfected with Myc-tagged LRRK1, LRRK2 or untagged Kv2.1 plasmid and probed with N341/12 (left) or N241A/34 (right) TC supe.

Product Details

Target

Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)

Target Description

Leucine Rich Repeat Kinase 1 is encoded by the gene LRRK1. LRRK1 is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily. LRRK1 is a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. LRRK1 is thought to play a role in the regulation of bone mass. LRRK1 is overexpressed in lymph node and uterus. Diseases associated with LRRK1 include Osteosclerotic Metaphyseal Dysplasia and Parkinson Disease 3, Autosomal Dominant.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N341/12

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

LRRK1 KIAA1790

Molecular Weight

>200 kDa

Antigen

Fusion protein amino acids 1695-2015 (C-terminus) of human LRRK1 (also known as Leucine-rich repeat serine/threonine-protein kinase 1 and KIAA1790, accession number Q38SD2); Mouse: 81% identity (263/321 amino acids identical); Rat: 79% identity (254/321 amino acids identical); Less than 50% identity with LRRK2; This NeuroMab antibody is considered "Restricted" and is therefore not available for commercial re-distribution on a for-profit basis.

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2315880

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with LRRK2

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)

UniProt Details

UniProt (Human): Q38SD2
UniProt (Immunogen Species): Q38SD2

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Anti-LRRK1 Antibody (N341/12)

Anti-LRRK1 Antibody
SKU: 75-347

Product Details

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Anti-LRRK1 Antibody (N341/12)

Anti-LRRK1 Antibody SKU: 75-347

Product Details

Anti-LRRK1 Antibody
SKU: 75-347