Leucine Rich Repeat Kinase 1 is encoded by the gene LRRK1. LRRK1 is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily. LRRK1 is a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. LRRK1 is thought to play a role in the regulation of bone mass. LRRK1 is overexpressed in lymph node and uterus. Diseases associated with LRRK1 include Osteosclerotic Metaphyseal Dysplasia and Parkinson Disease 3, Autosomal Dominant.
Fusion protein amino acids 1695-2015 (C-terminus) of human LRRK1 (also known as Leucine-rich repeat serine/threonine-protein kinase 1 and KIAA1790, accession number Q38SD2); Mouse: 81% identity (263/321 amino acids identical); Rat: 79% identity (254/321 amino acids identical); Less than 50% identity with LRRK2; This NeuroMab antibody is considered "Restricted" and is therefore not available for commercial re-distribution on a for-profit basis.
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with LRRK2
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.