Immunoblot of crude membrane fractions from adult heart ventricle (V) and brain (B) from wild-type (WT) and Kvß1 knockout (Kvβ1) mice probed with K47/42 (Kvβ1.2, top) and K17/70 (Kvβ2, bottom). Data courtesy of Jeanne Nerbonne, Washington University SOM. Reproduced with permission from 2005 Aimond et al. Circ Res.
Anti-Kvbeta1.2 K+ Channel Antibody
Kvbeta1.2 K+ channel
Voltage-gated potassium channel subunit beta-1 or Kvß1.1 is encoded by the gene KCNAB1. Kvß1.1 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Alternative splicing of KCNAB1 allows for three distinct proteins to be made, Kvß1.1, Kvß1.2, and Kvß1.3. Each of these has a unique N terminus. Kvß1.1 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on the channel members. Kvß1 is predominantly expressed in brain and found in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum. Diseases associated with this gene include Episodic Ataxia, Type 1 and Familial Temporal Lobe Epilepsy, 3
IHC, IP, WB
Synthetic peptide amino acids 9-28 (ADIPSPKLGLPKSSESALKC, unique Nterminus) of human Kv1.2 (accession number NP_003462); Rat: 100% identity (20/20 amino acids identical)
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.