Anti-Kv1.2 Potassium Channel Subunit Antibody (L76/36)

Name: Anti-Kv1.2 Potassium Channel Subunit Antibody
Brand: NeuroMab
SKU: 75-314
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

KO Validated

1 Citation

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

L76/36

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

KCNA2

Molecular Weight

80 kDa

Go to Full Product Details

Adult rat brain membrane immunoblot.

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-Kv1.2 Potassium Channel Subunit Antibody

Product Details

Target

Kv1.2 potassium channel subunit

Target Description

Potassium voltage-gated channel subfamily A member 2 (also known as Potassium Voltage-Gated Channel A Member 2 , Shaker-Related Subfamily, Member 2 or Voltage-Gated Potassium Channel Protein Kv1.2, or KCNA2) is a member of the Kv family of potassium channels. Kv1.2 contains six membrane spanning domains and belongs to the delayer rectifier class of potassium channels. Kv2.1 mediates the voltage dependent potassium ion permeability of excitable membranes. Kv1.2 binds PDZ domains of DLG1, DLG2 and DLG4. Kv1.2 is found primarily in the brain (at the axon initial segment, axon preterminals and juxtaparanode domains), central nervous system, but also in the cardiovascular system. Kv2.1 has been implicated in epileptic encephalopathy, early infantile, and episodic ataxia, type 1.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L76/36

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

KCNA2

Molecular Weight

80 kDa

Antigen

Fusion protein amino acids 428-499 (QYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSN EDFREENLKTANCTLANTNYVNITKMLTDV, cytoplasmic C-terminus) of human Kv1.2 (accession number P16389) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315859

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2)

UniProt Details

UniProt (Human): P16389
UniProt (Immunogen Species): P16389

Manning CF, Bundros AM, Trimmer JS. (2012), 'Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance..' PLoS One.. 10.1371/journal.pone.0038313.

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Anti-Kv1.2 Potassium Channel Subunit Antibody (L76/36)

Available Conjugates

Anti-Kv1.2 Potassium Channel Subunit Antibody
SKU: 75-314

Bulk Order Anti-Kv1.2 Potassium Channel Subunit Antibody

Product Details

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Anti-Kv1.2 Potassium Channel Subunit Antibody (L76/36)

Available Conjugates

Anti-Kv1.2 Potassium Channel Subunit Antibody SKU: 75-314

Bulk Order Anti-Kv1.2 Potassium Channel Subunit Antibody

Product Details

Anti-Kv1.2 Potassium Channel Subunit Antibody
SKU: 75-314