Solute carrier family 12 member 5 is encoded by the gene SLC12A5 and belongs to the SLC12 family of cation-coupled chloride transporters. SLC12A5 is an integral membrane K-Cl cotransporter that mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. Diseases associated with SLC12A5 include Early Infantile Epileptic Encephalopathy 34 and Idiopathic Generalized Epilepsy 14.
ICC, IHC, WB
Slc12a5 Kcc2 Kiaa1176
Fusion protein amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2b (also known as Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, K-Cl cotransporter 2, Neuronal K-Cl cotransporter,Furosemide-sensitive K-Cl cotransporter and Erythroid K-Cl cotransporter 2, accession number Q63633); Human: 96% identity (108/112 residues identical); Mouse: 95% identity (107/112 residues identical); 100% identity with KCC2a; Less than 40% identity with KCC1, KCC3, KCC4
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.