Solute carrier family 12 member 5 is encoded by the gene SLC12A5 and belongs to the SLC12 family of cation-coupled chloride transporters. SLC12A5 is an integral membrane K-Cl cotransporter that mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. Diseases associated with SLC12A5 include Early Infantile Epileptic Encephalopathy 34 and Idiopathic Generalized Epilepsy 14.
ICC, IHC, WB
Slc12a5 Kcc2 Kiaa1176
Fusion protein amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2b (also known as Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, K-Cl cotransporter 2, Neuronal K-Cl cotransporter,Furosemide-sensitive K-Cl cotransporter and Erythroid K-Cl cotransporter 2, accession number Q63633); Human: 96% identity (108/112 residues identical); Mouse: 95% identity (107/112 residues identical); 100% identity with KCC2a; Less than 40% identity with KCC1, KCC3, KCC4
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not react with KCC1, KCC3 or KCC4
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (mKCC2) (Neuronal K-Cl cotransporter)