Anti-IP3 Receptor, Type 1 Antibody (L24/18)
Our Anti-IP3 receptor, type 1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L24/18. It detects human, mouse, and rat IP3 receptor, type 1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].](http://www.antibodiesinc.com/cdn/shop/files/75-035-l24-18-wb-3_{width}x.png?v=1702670832)
Adult rat cerebellar immunohistochemistry.
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].](http://www.antibodiesinc.com/cdn/shop/files/75-035-l24-18-wb-3_1024x.png?v=1702670832)
Product Specific References for Applications and Species
- Immunocytochemistry: Mouse | Rat
- Immunohistochemistry: Human | Mouse
- Immunoprecipitation: Human | Mouse | Rat
- Western Blot: Canine | Human | Mouse | Rat
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 37838947 | not listed | Horvath, JD, et al. 2023. α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity. Cell Reports, 113244. |
| 29321137 | 1:200 | Kong, J.N., et al. 2018. Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes. Journal of Lipid Research, 488-506. |
| 25270259 | not listed | Fos, C., et al. 2014. Association of the EF-hand and PH domains of the guanine nucleotide exchange factor SLAT with IP₃ receptor 1 promotes Ca²⁺ signaling in T cells.. Science Signaling, ra93. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 27147559 | 1:100 | Wang, Q., et al. 2016. Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries. American Journal of Physiology-Cell Physiology, C1001-C1009. |
| 23670089 | 1:100 | Seo, J.W., et al. 2013. Proteomic analysis of primary cultured rat cortical neurons in chemical ischemia.. Neurochemical Research, 1648-1660. |
| 20713546 | 1:100 | Zhao, G., et al. 2010. Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells.. The Journal of General Physiology, 283-291. |
| 18799650 | 1:100 | Zhao, G., et al. 2008. Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries.. American Journal of Physiology-Cell Physiology, C1376-C1384. |
| Immunohistochemistry: Human | ||
| PMID | Dilution | Publication |
| 35328381 | 1:50 | Foulon, A., et al. 2022. Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool?. International journal of molecular sciences, 2962. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 27162368 | 1:200 | Spassieva, S.D., et al. 2016. Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency. PNAS USA, 5928-5933. |
| 22331418 | 1:500 | Westcott, E.B., et al. 2012. Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles.. The Journal of Physiology, 1849-1869. |
| 20649839 | 1:600 | Fang, F., et al. 2010. Neurosteroid transport by the organic solute transporter OSTα-OSTβ.. Journal of Neurochemistry, 220-233. |
| 18946029 | not listed | Isakson, B.E., et al. 2008. Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication.. Journal of Cell Science, 3664-3673. |
| Immunoprecipitation: Human | ||
| PMID | Dilution | Publication |
| 28506928 | 1ug | Wilson, L.S., et al. 2017. Distinct phosphodiesterase 5A-containing compartments allow selective regulation of cGMP-dependent signalling in human arterial smooth muscle cells. Cell Signalling, 204-211. |
| 18757735 | not listed | Wilson, L.S., et al. 2008. Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions.. PNAS USA, 13650-13655. |
| Immunoprecipitation: Mouse | ||
| PMID | Dilution | Publication |
| 29386119 | not listed | Christie, M.J., et al. 2018. Effects of intrauterine growth restriction on Ca2+-activated force and contractile protein expression in the mesenteric artery of 1-year-old Wistar-Kyoto rats. Journal of Physiology and Biochemistry, 111-121. |
| Immunoprecipitation: Rat | ||
| PMID | Dilution | Publication |
| 20713546 | not listed | Zhao, G., et al. 2010. Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells.. The Journal of General Physiology, 283-291. |
| Western Blot: Canine | ||
| PMID | Dilution | Publication |
| 28381466 | not listed | Tadevosyan, A., et al. 2017. Intracellular angiotensin‐II interacts with nuclear angiotensin receptors in cardiac fibroblasts and regulates rna synthesis, cell proliferation, and collagen secretion. . Journal of the American Heart Association, 6(4), p., e004965. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 35328381 | 1:500 | Foulon, A., et al. 2022. Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool?. International journal of molecular sciences, 2962. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 32675284 | not listed | Argent, L., et al. 2020. Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology. Journal of Biological Chemistry, 12716-12726. |
| 29386119 | not listed | Christie, M.J., et al. 2018. Effects of intrauterine growth restriction on Ca2+-activated force and contractile protein expression in the mesenteric artery of 1-year-old Wistar-Kyoto rats. Journal of Physiology and Biochemistry, 111-121. |
| 24259518 | 1:1000 | Dagley, L.F., et al. 2014. Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain.. Proteomics., 241-261. |
| 24097979 | 1:1000 | Abou-Saleh, H., et al. 2013. Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility.. The Journal of Biological Chemistry, 32941-32951. |
| 19193873 | not listed | Tang, T.S., et al. 2009. Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington''s disease mouse model.. Journal of Neuroscience, 1257-1266. |
| 19036964 | not listed | Chen, X., et al. 2008. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.. Journal of Neuroscience, 12713-12724. |
| 18946029 | not listed | Isakson, B.E., et al. 2008. Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication.. Journal of Cell Science, 3664-3673. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 24726828 | 1:1000 | Tykocki, N.R., et al. 2015. Divergent signaling mechanisms for venous versus arterial contraction as revealed by endothelin-1.. Journal of Vascular Surgery, 721-733. |
| 23670089 | not listed | Seo, J.W., et al. 2013. Proteomic analysis of primary cultured rat cortical neurons in chemical ischemia.. Neurochemical Research, 1648-1660. |
| 21098487 | not listed | Adebiyi, A., et al. 2011. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells.. The Journal of Biological Chemistry, 4341-4348. |
| 20713546 | not listed | Zhao, G., et al. 2010. Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells.. The Journal of General Physiology, 283-291. |
| 18616558 | 1:3 (supe) | Ingram, E.A., et al. 2009. Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy.. Epilepsia, 56-64. |
| Additional Publications: Unspecified | ||
| PMID | Publication | |
| 31927696 | Christie, M.J., et al. 2020. Effects of intrauterine growth restriction on Ca2+-activated force and contractile protein expression in the mesenteric artery of 1-year-old Wistar-Kyoto rats. Journal of Physiology and Biochemistry, 111-121. | |