Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged INPP4b or untagged Kv2.1 plasmid and probed with N171/17 (left) and N86/8 (right) TC supe.
Inositol polyphosphate 4-phosphatase type II is encoded by the gene INPP4B. INPP4B is a member of the inositol 3,4-bisphosphate 4-phosphatase family. INPP4B is an enzyme involved in phosphatidylinositol pathways. This enzyme catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-triphosphate, and inositol 3,4-triphosphate. The lipid phosphatase activity is critical for tumor suppressor function. INPP4B activity modulates cell cycle progression and cell survival. INPP4B is widely expressed with the highest levels occuring in the skeletal muscle and heart. No disorders were found to be associated with INPP4B.
Fusion protein amino acids 395-518 of human INPP4b (also known as Type II inositol-3,4-bisphosphate 4-phosphate, accession number O15327); Mouse: 87% identity (109/124 amino acids identical); Rat: 87% identity (109/125 amino acids identical); Less than 40% identity with INPP4a
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with INPP4a
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Type II inositol 3,4-bisphosphate 4-phosphatase (EC 220.127.116.11) (Inositol polyphosphate 4-phosphatase type II)