Anti-INPP4b Antibody (N171/17)

Name: Anti-INPP4b Antibody
Brand: NeuroMab
SKU: 75-218
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse

Clone

N171/17

Applications

ICC, WB

Host Species

Mouse

Format

Purified

Gene Name

INPP4B

Molecular Weight

100 kDa

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Immunoblot of Inpp4b+/+ or Inpp4b−/− mouse embryonic fibroblasts treated with vehicle or apilimod 10 nM for 48 h and assessed for protein levels of Inpp4b, LC3, and Beta actin as loading control. Image from publication CC-BY-4.0. PMID: 35760104

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged INPP4b or untagged Kv2.1 plasmid and probed with N171/17 (left) and N86/8 (right) TC supe.

Volume: 100 µL

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Price:

$308

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Product Details

Target

INPP4b

Target Description

Inositol polyphosphate 4-phosphatase type II is encoded by the gene INPP4B. INPP4B is a member of the inositol 3,4-bisphosphate 4-phosphatase family. INPP4B is an enzyme involved in phosphatidylinositol pathways. This enzyme catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-triphosphate, and inositol 3,4-triphosphate. The lipid phosphatase activity is critical for tumor suppressor function. INPP4B activity modulates cell cycle progression and cell survival. INPP4B is widely expressed with the highest levels occuring in the skeletal muscle and heart. No disorders were found to be associated with INPP4B.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N171/17

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

INPP4B

Molecular Weight

100 kDa

Antigen

Fusion protein amino acids 395-518 of human INPP4b (also known as Type II inositol-3,4-bisphosphate 4-phosphate, accession number O15327); Mouse: 87% identity (109/124 amino acids identical); Rat: 87% identity (109/125 amino acids identical); Less than 40% identity with INPP4a

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_11001557

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with INPP4a

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Type II inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II)

UniProt Details

UniProt (Human): O15327
UniProt (Immunogen Species): O15327

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Anti-INPP4b Antibody (N171/17)

Anti-INPP4b Antibody
SKU: 75-218

Bulk Order Anti-INPP4b Antibody

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Anti-INPP4b Antibody (N171/17)

Anti-INPP4b Antibody SKU: 75-218

Bulk Order Anti-INPP4b Antibody

Product Details

Anti-INPP4b Antibody
SKU: 75-218