Primary Antibody
Human, Mouse, Rat
N138/6
ICC, WB
Mouse
Purified
LRRK2 PARK8
>200 kDa
- Nucifora FC Jr, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, Dawson TM, Smith W, Lim KL, Ross CA. (), 'Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1..' Nature Communications. 10.1038/ncomms11792.
- Davies P, Hinkle KM, Sukar NN, Sepulveda B, Mesias R, Serrano G, Alessi DR, Beach TG, Benson DL, White CL, Cowell RM, Das SS, West AB, Melrose HL. (2013), 'Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies..' Biochemical Journal. 10.1042/BJ20121742.
- Berwick DC, Javaheri B, Wetzel A, Hopkinson M, Nixon-Abell J, Grannò S, Pitsillides AA, Harvey K. (2017), 'Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling..' Molecular Neurodegeneration. 10.1186/s13024-017-0153-4.
- Cho HJ, Yu J, Xie C, Rudrabhatla P, Chen X, Wu J, Parisiadou L, Liu G, Sun L, Ma B, Ding J, Liu Z, Cai H. (2014), 'Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export..' The EMBO Journal. 10.15252/embj.201487807.
- Cho HJ, Liu G, Jin SM, Parisiadou L, Xie C, Yu J, Sun L, Ma B, Ding J, Vancraenenbroeck R, Lobbestael E, Baekelandt V, Taymans JM, He P, Troncoso JC, Shen Y, Cai H. (2013), 'MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein..' Human Molecular Genetics. 10.1093/hmg/dds470.
- Berwick DC, Harvey K. (2012), 'LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6..' Human Molecular Genetics. 10.1093/hmg/dds342.
- Doggett EA, Zhao J, Mork CN, Hu D, Nichols RJ. (2012), 'Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition..' Journal of Neurochemistry. 10.1111/j.1471-4159.2011.07537.x.
- Andres-Mateos E, Mejias R, Sasaki M, Li X, Lin BM, Biskup S, Zhang L, Banerjee R, Thomas B, Yang L, Liu G, Beal MF, Huso DL, Dawson TM, Dawson VL. (2009), 'Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)..' Journal of Neuroscience. 10.1523/JNEUROSCI.4357-09.2009.
- Reyniers L, Del Giudice MG, Civiero L, Belluzzi E, Lobbestael E, Beilina A, Arrigoni G, Derua R, Waelkens E, Li Y, Crosio C, Iaccarino C, Cookson MR, Baekelandt V, Greggio E, Taymans JM. (), 'Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways..' Journal of Neurochemistry. 10.1111/jnc.12798.
- Vancraenenbroeck R, De Raeymaecker J, Lobbestael E, Gao F, De Maeyer M, Voet A, Baekelandt V, Taymans JM. (), 'In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2..' Frontiers in Molecular Neuroscience. 10.3389/fnmol.2014.00051.
- Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL. (), 'Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease..' Cell. 10.1016/j.cell.2014.01.064.
- Parisiadou L, Yu J, Sgobio C, Xie C, Liu G, Sun L, Gu XL, Lin X, Crowley NA, Lovinger DM, Cai H. (), 'LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity..' Nature Neuroscience. 10.1038/nn.3636.
- Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar MPM, Plun-Favreau H, Giunti P, Tooze SA, Bandopadhyay R, Lewis PA. (), 'Inhibition of LRRK2 kinase activity stimulates macroautophagy..' Biochimica et Biophysica Acta. 10.1016/j.bbamcr.2013.07.020.
- Xiong Y, Yuan C, Chen R, Dawson TM, Dawson VL. (), 'ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2..' Journal of Neuroscience. 10.1523/JNEUROSCI.4566-11.2012.
- Gómez-Suaga P, Luzón-Toro B, Churamani D, Zhang L, Bloor-Young D, Patel S, Woodman PG, Churchill GC, Hilfiker S. (), 'Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP..' Human Molecular Genetics. 10.1093/hmg/ddr481.