Anti-Chapsyn-110/PSD-93 Antibody (N18/30)

Name: Anti-Chapsyn-110/PSD-93 Antibody
Brand: NeuroMab
SKU: 75-057
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Dlg2 Dlgh2

Molecular Weight

110 kDa

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Adult rat brain hippocampus immunohistochemistry.

Immunoblot against crude membranes from whole adult mouse brain (MBM) or rat brain (RBM) and from human cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] probed with N18/30 (left) or N52A/42 (right) TC supe.

Immunoblot against crude membranes from whole adult rat brain (RBM) or hippocampi (MHM) from adult PSD-93/Chapsyn-110 knockout (KO) or wild-type (WT) mice. Mouse samples courtesy of Richard Huganir (Johns Hopkins University).

Immunofluorescence staining of cultured rat hippocampal neurons with N18/30 (red), K13/31 (Kv1.4, green) and rabbit anti- MAP2 (blue). Image courtesy of Yasuhiro Ogawa and Matthew Rasband (Baylor College of Medicine).

Adult rat brain hippocampus immunohistochemistry.

Product Details

Target

Chapsyn-110/PSD-93

Target Description

PSD-93/Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2 and Dlg2) is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains a guanylate kinase-like domain, 3 PDZ domains and 1 SH3 domain. Chapsyn110 binds to NMDA receptor subunits and Shaker K+ channel subunits to aid in forming a multiprotein scaffold which clusters receptors, ion channels, cytoskeletal protiens and other cell signaling proteins. In this manner, it plays a key role in postsynaptic targeting. It is found in brain in neuronal cells and located at the cell synapse, postsynaptic cell membrane and postsynaptic density. Chapsyn110 has been implicated in chronic pain, bilateral retinoblastoma and schizophrenia.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N18/30

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Dlg2 Dlgh2

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 1-852 of rat Chapsyn-110 (accession number Q63622); Human: 94% identity (826/870 amino acids identical); Mouse=99% identity (846/852 amino acids identical)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2277296

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against other MAGUK family members PSD-95, SAP97, SAP102 expressed in transfected cells

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

UniProt Details

UniProt (Human): Q15700
UniProt (Immunogen Species): Q63622

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Anti-Chapsyn-110/PSD-93 Antibody (N18/30)

Anti-Chapsyn-110/PSD-93 Antibody
SKU: 75-057

Product Details

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Anti-Chapsyn-110/PSD-93 Antibody (N18/30)

Anti-Chapsyn-110/PSD-93 Antibody SKU: 75-057

Product Details

Anti-Chapsyn-110/PSD-93 Antibody
SKU: 75-057