Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from wild-type (WT) and lethargic (lh/lh) mice (left) Lethargic mice courtesy of Dr. Jeff Noebels, Baylor College of Medicine.
Anti-Cavbeta4 Ca2+ Channel Antibody
Cavbeta4 Ca2+ channel
Voltage-dependent L-type calcium channel subunit beta-4 or Cav ß4 is encoded by the gene CACNB4. Cavß4 is a cytoplasmic subunit of voltage-sensitive calcium channels.These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cav ß4 is expressed predominantly in the brain (cerebellum) and kidney. Diseases associated with this gene include Episodic Ataxia, Type 5 and Epilepsy.
IHC, IP, WB
Synthetic peptide amino acids 458-474 of rat Cav4 (DENYHNERARKSRNRLS; D4A055); Human: 100% identity; Mouse=100% identity
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity against rat Cavβ1b, Cavβ2a, and Cavβ3 in transfected cells
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.