Anti-ATM (C-terminal region) Antibody (M361)
Our ATM (C-terminal region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human ATM (C-terminal region) and is Protein A purified. It is great for use in WB, IP, ICC, FC.
SKU: AM3611
Product Details
ATM (C-terminal region)
Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer predisposition. Activation of ATM after DNA damage involves Cdk5 mediated phosphorylation of Ser-794 followed by autophosphorylation at Ser-1891. Active ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis and DNA repair. The Cdk5–ATM pathway regulates phosphorylation and function of the ATM targets p53 and H2AX in postmitotic neurons. Other known substrates of ATM include Chk2, Chk1, CtIP, 4E-BP1, BRCA1, RPA3, SMC1, FANCD2, Rad17, Artemis, Nbs1, and the I-2 regulatory subunit of PP1. Thus, activation of Cdk5 by DNA damage may be an important initiator of ATM-dependent regulation of cell cycle checkpoints.
Protein A Purified
Monoclonal
M361
IgG2b
Flow, ICC, IP, WB
Mouse
ATM
370
Clone M361 was generated from a recombinant sequence corresponding to amino acids in the C-terminal region of human ATM.
Human
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Liquid
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
WB: 1:1000
ICC: 1:100
IP: 1:100
ICC: 1:100
IP: 1:100
Unconjugated
This antibody detects a 370 kDa* protein corresponding to the molecular mass of ATM on SDS-PAGE immunoblots of human A431 and Jurkat cells.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
United States
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
ataxia telangiectasia mutated, AT1 ATDC TEL1 TELO1
UniProt (Human): Q13315
UniProt (Immunogen Species): Q13315
UniProt (Immunogen Species): Q13315