Anti-Ciliary neurotrophic factor (CNTF) Antibody

Name: Anti-Ciliary neurotrophic factor (CNTF) Antibody
Brand: Biosensis
SKU: C-1526-500
Price: 337.0 USD
Availability: InStock

Our Anti-Ciliary neurotrophic factor (CNTF) chicken polyclonal primary antibody detects human, mouse, and rat Ciliary neurotrophic factor (CNTF), and is affinity-purified. It is validated for use in ELISA, WB.

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, WB

Host Species

Chicken

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Data Sheet

SKU: C-1526-500

Volume/Size: 500 µL

Variant

Price:

$337.00

Quantity:

Product Details

Target

Ciliary neurotrophic factor (CNTF)

Scientific Background

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgY

Applications

ELISA, WB

Host Species

Chicken

Immunogen

Mixture of two peptides from human CNTF (11-25 and 186-200 aa). Both peptides are highly conserved among human and mouse.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.

Physical State

Liquid

Buffer

PBS with 0.02% sodium azide.

Dilution Ranges

WB: 1:500-1:2000
IHC: 1:50-1:500
ELISA: 1:500-1:2000

Conjugate

Unconjugated

Specificity

CNTF, Cross reactivity to other species is expected.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Ciliary neurotrophic factor; CNTF;

UniProt ID

P26441

Shipping

2-8°C (on cold packs)

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Anti-Ciliary neurotrophic factor (CNTF) Antibody

SKU: C-1526-500

Product Details

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