Anti-Ankyrin-G Recombinant Chicken Chimeric mAb (N106/36)

Name: Anti-Ankyrin-G Recombinant Chicken Chimeric mAb
Brand: Aves Labs
SKU: 78-146-CF
Price: 510.0 USD
Availability: InStock

Our chicken Anti-Ankyrin-G (Staining) recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N106/36. It detects feline, hamster, human, mouse, non-human primate, and rat Ankyrin-G (Staining) and is purified by affinity chromatography. It works in WB, IHC, ICC, IP, ELISA.

Anti-Ankyrin-G Recombinant Chicken Chimeric mAb

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Applications

ELISA, ICC, IHC, IP, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

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Data Sheet

SKU: 78-146-CF

Volume: 100 µL

Variant

Price:

$510.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Ankyrin-G (Staining)

Scientific Background

Ankyrin-G (ankyrin 3) is a member of the Ankyrin family which consists of Ankyrin R (1), Ankyrin B (2) and Ankyrin G (3) all of which are expressed in the nervous system. Ankyrins are structural proteins that aid in the attachment of integral membrane proteins with the spectrin-actin cytoskeleton, and thus targets voltage-gated sodium channels, potassium channels, cell adhesion molecules and others at the nodes of Ranvier and axonal initial segments (AIS). Variants in Ankyrin G have been linked to bipolar disorder.

Format

Purified by affinity chromatography

Concentration

1 mg/mL

Clonality

Recombinant

Clone

N106/36

Isotype

IgY

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Chicken

Gene Name

ANK3

Molecular Weight

>200 kDa

Excitation / Emission

Unconjugated

Immunogen

Fusion protein ~1000 amino acids of Ankyrin-G (accession number E9PE32) produced recombinantly in E. Coli

Immunogen Species

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N106/36 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N106/36 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and buffer exchanged into 1X PBS.

Buffer

PBS

Dilution Ranges

WB: 1:1000

Conjugate

Unconjugated, Carrier Free

Specificity

Does not cross-react with Ankyrin-B

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Ankyrin-3 (ANK-3) (Ankyrin-G)

UniProt ID

E9PE32

Shipping

Shipped on ice packs

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Anti-Ankyrin-G Recombinant Chicken Chimeric mAb (N106/36)

SKU: 78-146-CF

Product Details

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