AM1-44 Nerve Terminal Dye

Name: AM1-44 Nerve Terminal Dye
Brand: Antibodies Incorporated
SKU: 81-8019
Price: 339.0 USD
Availability: InStock

Our AM1-44 Nerve Terminal Dye is a fixable, activity-dependent fluorescent nerve terminal probe. It is a useful tool for synapse studies where subsequent fluorescent immunochemistry is desired.

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Applications

EM, ICC, IHC

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Data Sheet

SKU: 81-8019

Size: 1 mg

Variant

Price:

$339.00

Quantity:

Ships: 1-5 business days

Product Details

Scientific Background

Nerve terminal dyes have highly hydrophilic, cationically charged head groups at one end with lipophilic tails at the other end. They are virtually non-fluorescent in aqueous solution, but become intensely fluorescent in membranes. Following nerve stimulation, the dye molecules are internalized in newly formed endocytic vesicles. During exocytosis, the dyes are released from the vesicles along with neurotransmitters, causing a decrease in fluorescence signal. As a result, the change in fluorescent intensity reflects the amount of endocytosis/exocytosis or synaptic activity. AM1-44 is a version of AM1-43 with improved fixability. The dye can also be used as a general probe for following endocytosis. AM1-44 probe functions similarly as AM1-43, except that AM1-44 has lipophilic tails that are each one carbon longer than those of AM1-43, resulting in better fixability.

Applications

EM, ICC, IHC

Molecular Weight

587.5 Da

Excitation / Emission

Ex: 480 nm, Em: 598 nm (in membranes)

Storage

Store at 2°C to 8°C, with desiccant; protect from light.

Physical State

Solid

Specificity

For use in real-time imaging of live/intact cells and cells fixed after staining in formaldehyde.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

Stable for 12 months after date of receipt.

Shipping

Shipped at ambient temperature with desiccant; protected from light

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AM1-44 Nerve Terminal Dye

SKU: 81-8019

Product Details

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