Anti-Brain-derived neurotrophic factor (BDNF) Antibody

Name: Anti-Brain-derived neurotrophic factor (BDNF) Antibody
Brand: Biosensis
SKU: C-1517-500
Price: 337.0 USD
Availability: InStock

Our Anti-Brain-derived neurotrophic factor (BDNF) chicken polyclonal primary antibody detects human and mouse Brain-derived neurotrophic factor (BDNF), and is IgY. It is validated for use in ELISA.

Species Reactivity

Human, Mouse

Applications

ELISA

Host Species

Chicken

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Data Sheet

SKU: C-1517-500

Volume/Size: 500 µL

Variant

Price:

$337.00

Quantity:

Product Details

Target

Brain-derived neurotrophic factor (BDNF)

Scientific Background

BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

Format

IgY

Clonality

Polyclonal

Isotype

IgY

Applications

ELISA

Host Species

Chicken

Immunogen

Mixture of two human BDNF peptides (73-87 and 194-208 aa). Both peptides are highly conserved in human and mouse.

Immunogen Species

Human

Species Reactivity

Human, Mouse

Storage

Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.

Physical State

Liquid

Buffer

PBS with 0.02% Sodium Azide

Dilution Ranges

ELISA: 1:500-1:1000

Conjugate

Unconjugated

Specificity

Mammalian BDNF.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Brain-derived neurotrophic factor; Abrineurin; proBDNF;

UniProt ID

P23560

Shipping

2-8°C (on cold packs)

Technical Note 4 - Acid Extraction of Brain Tissue

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Anti-Brain-derived neurotrophic factor (BDNF) Antibody

SKU: C-1517-500

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