Vasoactive Intestinal Peptide (VIP) or PHM27 is encoded by the gene VIP and belongs to the glucagon family. VIP is a secreted peptide hormone and binds to the VIP receptors VIP R1 and VIP R2. Signaling through the receptors, VIP is involved diverse processes including vasodilation, regulation of blood pressure, stimulates myocardial contractility and neurotransmission. VIP is produced in many tissues including gut, pancreas, heart and brain. Diseases associated with this gene include Vipoma and Vasomotor Rhinitis.
Fusion protein amino acids 81-152 (mature protein) of human VIP (also known as Vasoactive intestinal peptide and Vasoactive intestinal polypeptide, cleaved into Intestinal peptide PHI-42 / PHV-42 for Peptide histidine valine 42 and Intestinal peptide PHM-27 for Peptide histidine methioninamide 27 / Intestinal peptide PHI-27 for Peptide histidine isoleucinamide 27, accession number P01282)
Rat: 92% identity (66/72 amino acids identical)
Mouse: 90% identity (65/72 amino acids identical)
50% identity with PACAP
VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]
TC Supernatant: AB_ 2619640
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.