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Products: Primary Antibodies

Anti-Pan-SAPAP Antibody (N127/31)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-156
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-156
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG2b

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC IHC WB

Target Description:

SAPAP1 (also known as disks large associated protein 1), SAPAP2 (also known as disks large associated protein 2), SAPAP3 (also known as disks large associated protein 3) and SAPAP4 (also known as disks large associated protein 4) proteins are members of the SAPAP or DLGAP family of proteins. SAPAP proteins function as scaffolding proteins at excitatory synapses. SAPAP proteins interact with PSD95 family and Shank family proteins to anchor/target neurotransmitter receptors and signaling molecules to the postsynaptic membrane of excitatory synapses.

Immunogen:

Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1 (also known as disks large-associated protein 1, guanylate kinase-associated protein, GKAP, SAP90/PSD-95-associated/binding protein 1, accession number P97836); Mouse: 99% identity (200/201 amino acids identical); Human: 99% identity (199/201 amino acids identical); 55-65% identity with other SAPAPs

Cross Reactivity:

Cross-reacts with other SAPAPs

Protein Name(s):

Pan-SAPAP

Gene Name(s):

DLGAP1 DAP1 GKAP DLGAP2 C8orf68 DAP2 ERICH1-AS1 DLGAP3 DAP3 DLGAP4 DAP4 KIAA0964 SAPAP4

Antibody Registry ID:

Purified: AB_10671947
TC Supernatant: AB_10697886


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

120 kDa (SAPAP2), 110 kDa (SAPAP1/3/4)


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.