Human Mouse Rat
ICC IHC WB
SAPAP1 (also known as disks large associated protein 1), SAPAP2 (also known as disks large associated protein 2), SAPAP3 (also known as disks large associated protein 3) and SAPAP4 (also known as disks large associated protein 4) proteins are members of the SAPAP or DLGAP family of proteins. SAPAP proteins function as scaffolding proteins at excitatory synapses. SAPAP proteins interact with PSD95 family and Shank family proteins to anchor/target neurotransmitter receptors and signaling molecules to the postsynaptic membrane of excitatory synapses.
Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1 (also known as disks large-associated protein 1, guanylate kinase-associated protein, GKAP, SAP90/PSD-95-associated/binding protein 1, accession number P97836); Mouse: 99% identity (200/201 amino acids identical); Human: 99% identity (199/201 amino acids identical); 55-65% identity with other SAPAPs
Cross-reacts with other SAPAPs
DLGAP1 DAP1 GKAP DLGAP2 C8orf68 DAP2 ERICH1-AS1 DLGAP3 DAP3 DLGAP4 DAP4 KIAA0964 SAPAP4
TC Supernatant: AB_10697886
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
120 kDa (SAPAP2), 110 kDa (SAPAP1/3/4)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.