Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. Members of the Kv5-Kv11 families code for “silent subunits” that do not express as functional homomultimers. In heterologous expression systems, silent subunits can coassemble with Kv2 and Kv3 subunits and modulate the biophysical characteristics of the latter subunits (Yan L. et al., 2004).
Fusion protein amino acids 1-163 (cytoplasmic N-terminus) of mouse Kv8.2 (also known as Potassium voltage-gated channel subfamily V member 2, Kcnv2 and rCG_63626, accession number Q8CFS6)
Rat: 85% identity (138/163 amino acids identical)
Human: 70% identity (115/164 amino acids identical)
Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2)
TC Supernatant: AB_2532091
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.