Products: Primary Antibodies

Anti-IRSp53/BAIAP2 Antibody (L117/1)

from NeuroMab

PRODUCT OPTIONS

Brand	Catalog #	Option	Volume	Concentration	Price
Brand	Catalog # 75-449	Option Purified	Volume 100 µL	Concentration 1 mg/mL	Price $275.00
Brand	Catalog # 73-449	Option TC Supernatant	Volume 5 mL	Concentration Lot dependent	Price $275.00

"TC Supernatant" vs. "Purified"

TC Supernatant
Hybridoma tissue-culture supernatant (5mL) generally containing 10-50 ug/mL monoclonal antibody (clone-dependent) can be a very economical choice. Supernatant is suitable for most applications including Western Blot, immunocytochemistry, immunohistochemistry etc. For applications requiring higher antibody concentration or purity (such as immunoprecipitation, microinjection, or conjugation) it is recommended that you purchase the purified form of the antibody (supplied at 1mg/mL).

Purified mAbs
Produced by in vitro bioreactor culture of hybridoma lines followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody at 1mg/mL.

Validation Images

Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Human Mouse Rat

Applications:

AT ICC IHC WB

Target Description:

Brain-specific angiogenesis inhibitor 1-associated protein 2 or IRSp53/BAIAP2 is encoded by the gene BAIAP2 and is a MAGUK (membrane-associted guanylase kinase homolog) family. BAIAP2 is an adaptor protein which links G-proteins in the membrane to cytoplasmic proteins and is involved in cell processes including regulation of the actin cytoskeleton, neurite growth and the promotion of filipodia formation. Multiple isoforms of BAIAP2 exist with differential tissue expression. Diseases associated with BAIAP2 include Dentatorubral-Pallidoluysian Atrophy and Attention Deficit-Hyperactivity Disorder.

Immunogen:

Fusion protein amino acids 1-250 (N-terminus) of human BAIAP2 (also known as Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI-associated protein 2, BAI1-associated protein 2, Insulin receptor substrate p53/p58, Insulin receptor substrate protein of 53 kDa, Insulin receptor tyrosine kinase 53 kDa substrate, Insulin receptor tyrosine kinase substrate protein p53, Fas ligand-associated factor 3, BAP2, IRS-58, IRSp53/58, IRSp53 and FLAF3, accession number Q9UQB8)
Mouse: 97% identity (243/250 amino acids identical)
Rat: 97% identity (242/250 amino acids identical)
50% identity with BAIAP2L1

Protein Name(s):

Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)

Gene Name(s):

BAIAP2

Antibody Registry ID:

Purified: AB_2651164
TC Supernatant: AB_2619741

Antibody Validation and Application Notes

This antibody has been validated using the following assays:

Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:

This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

50-60 kDa

Quality Control

The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.