Products: Primary Antibodies
PRODUCT OPTIONS
Catalog # | Option | Volume | Concentration | Price* | |
---|---|---|---|---|---|
Catalog # 75-257 |
Option Purified |
Volume 100 µL |
Concentration 1 mg/mL |
Price $269.00 |
|
Catalog # 73-257 |
Option TC Supernatant |
Volume 5 mL |
Concentration Lot dependent |
Price $269.00 |
Overview
NeuroMab
Monoclonal
Mouse
IgG2b
Human Mouse Rat
ICC WB
Fusion protein amino acids 808-874 (cytoplasmic loop between repeat II and III) of rat Cav1.2 (also known as Voltage-dependent L-type calcium channel subunit alpha-1C, CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1, Brain class C and MELC-CC, accession number Q5S007)
Mouse: 100% identity (67/67 amino acids identical)
Human: 86% identity (58/67 amino acids identical) <50% identity with other Cav1 channels
Does not cross-react with Cav1.3
Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1
Purified: AB_11000167
TC Supernatant: AB_11001554
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
240 kDa
Quality Control
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
Citations and References
- Perissinotti PP1, Ethington EA1, Almazan E1, Martínez-Hernández E1, Kalil J1, Koob MD2, Piedras-Rentería ES3.. (2015), 'Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice..' Front Cell Neurosci.. 10.3389/fncel.2014.00444.
- Perissinotti PP1, Ethington EG1, Cribbs L2, Koob MD3, Martin J4, Piedras-Rentería ES5.. (2014), 'Down-regulation of endogenous KLHL1 decreases voltage-gated calcium current density..' Cell Calcium.. 10.1016/j.ceca.2014.03.002.
- Liu W1, Deng J2, Wang G1, Zhang C3, Luo X1, Yan D2, Su Q4, Liu J5.. (201), 'KCNE2 modulates cardiac L-type Ca(2+) channel..' J Mol Cell Cardiol. . 10.1016/j.yjmcc.2014.03.013.
- Duan L1, Bhattacharyya BJ, Belmadani A, Pan L, Miller RJ, Kessler JA.. (2014), 'Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death..' Mol Neurodegener.. 10.1186/1750-1326-9-3.
- Narayanan D1, Bulley S, Leo MD, Burris SK, Gabrick KS, Boop FA, Jaggar JH.. (2013), 'Smooth muscle cell transient receptor potential polycystin-2 (TRPP2) channels contribute to the myogenic response in cerebral arteries..' J Physiol.. 10.1113/jphysiol.2013.258319.