Human Mouse Rat
Voltage-dependent L-type calcium channel subunit alpha-1C or Cav1.2 calcium channel (other names include as CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1 ) is a calcium channel encoded by the gene CACNA1C. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.2 is expressed in many tissues including smooth muscle, liver, kidney brain and heart. In brain, it can be detected in the hippocampus and brain cortex in the post-synaptic density and in neuronal cell bodies. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Mutations in the Cav1.2 gene have been associated with Timothy syndrome, Brugada syndrome 3 and Long QT syndrome 8.
Fusion protein amino acids 808-874 (cytoplasmic loop between repeat II and III) of rat Cav1.2 (also known as Voltage-dependent L-type calcium channel subunit alpha-1C, CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1, Brain class C and MELC-CC, accession number Q5S007)
Mouse: 100% identity (67/67 amino acids identical)
Human: 86% identity (58/67 amino acids identical) <50% identity with other Cav1 channels
Does not cross-react with Cav1.3
Cav1.2 Ca2+ channel
Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1
TC Supernatant: AB_11001554
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.